JUNIPER PUBLISHERS-Journal of Complementary Medicine & Alternative Healthcare
Cytotoxicity Effects of LPR-1®, CCE100 and ONCOBLOC® on a Panel of Cancer Cell Lines
Authored by Lim Yang Mooi,
LPR-1®, CCE100 and ONCOBLOC® are LPR-1® Standardized C. militaris (L.) Link Extract (LSc 1501)
Conventional Cordyceps extract (100X concentration) and ONCOBLOC® standardized novel C. militaris (L.) Link extract
(SLS-161), respectively. All these three extracts are obtained from C.
militaris through conventional and proprietary extraction processes. These
extracts possess a broad spectrum of chemoprotective properties against free
radicals and oxidative stress. In this study, the cytotoxicity ONCOBLOC® were assessed against 24 human cancer cell lines using
MTT of LPR-1®, CCE100 and cytotoxicity assay. In addition, the cytotoxic
effects of these extracts were benchmarked to chemotherapy drug, doxorubicin on
a panel of cancer cell lines. From the results obtained, LPR-1® showed cytotoxicity to HONE-1, NCI-H23 and Fa Du cells;
CCE100 caused cytotoxicity to HONE-1, Fa Du, T-47D, MCF-7 and U-2 OS cells;
whereas ONCOBLOC® exhibited cytotoxicity to HONE-1, FaDu, T-47D, MDA-
MB-231 and K-562. Among the 24 cancer cells, ONCOBLOC® showed the strongest cytotoxic effects against
nasopharyngeal carcinoma epithelial cell line (HONE-1), with the IC50 value of
15.34^g/mL. These preliminary results suggest that ONCOBLOC® possesses promising anti-cancer activities and could be
developed as a novel anticancer agent. Hence, more efficacy studies will be
carried to confirm its anti cancer properties.
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