Tuesday, November 27, 2018
Nongenomic Effect of T3 on the Na, K-ATPase Activity of Syncytiotrophoblast from Human Term Placenta
Authored by Fulgencio Proverbio
Several ion transport enzymes are positively regulated by genomic mechanisms, through the thyroid hormones T and T. However, there is evidence indicating that these hormones might also exert non genomic effects on different transporting enzymes. A normal activity of the Na, K-ATPase of syncytiotrophoblast is essential for ion homeostasis in this tissue, as well as for the growth and development of the fetus. In the current work it was studied the non genomic effect of thyroid hormones on the Na, K-ATPase activity of syncytiotrophoblast. The study was carried-out by incubating human term placental explants in the absence and presence of 10nMTor 350nMT and then isolating the syncytiotrophoblast plasma membranes and assaying them for Na, K-ATPase activity. The enzyme activity was also assayed for freshly prepared plasma membranes in the presence of (0-15)nMT or (0-500)nMT.
Changing Attitudes towards Assisted Reproduction and IVF
Authored by Kelly Oliver
If not so long ago pregnancy was something to be hidden, a private matter that required modesty in dress and behavior, now with sexy pregnant bodies and protruding baby bumps on the covers of tabloids every week, a new stigma is attached to Assisted Reproductive Technologies (ART), In Vitro Fertilization (IVF) and what goes on at fertility clinics, which is often showed in secrets. If a few decades ago a woman's pregnant body was considered obscene insofar as it was associated with sex—it was proof that she had sex--today the disconnect between sex and pregnancy made possible by new reproductive technologies appears as the new obscenity.
Semenoma Originated from an Ectopic Testis
Authored by Otheman Fahs
The authors report an observation of a meta static seminoma on an ectopic testicle in a 23 years old patient and discuss the epidemiological, diagnostic, therapeutic and evolutionary aspects of this entity. Clinical diagnosis is often difficult due to the diversity of clinical symptoms, the use of imaging, biological markers and percutaneous biopsyis essential to make the diagnosis. The anatomopathology and therapeutic aspects are similar to the testis in normal situations. Early diagnosis of these tumors involves the lowering of the cryptorchid testicles, because even if this lowering does not prevent the setumors, it allows better monitoring.
Monday, November 26, 2018
Be Wary of Using Poisson Regression to Estimate Risk and Relative Risk
Authored By Leigh Blizzard
Fitting a log binomial model to binary outcome data makes it possible to estimate risk and relative risk for follow-up data, and prevalence and prevalence ratios for cross-sectional data. However, the fitting algorithm may fail to converge when the maximum likelihood solution is on the boundary of the allowable parameter space. Some authorities recommend switching to Poisson regression with robust standard errors to approximate the coefficients of the log binomial model in those circumstances. This solves the problem of non-convergence, but results in errors in the coefficient estimates that may be substantial particularly when the maximum fitted value is large. The paradox is that the circumstances in which the modified Poisson approach is needed to overcome estimation problems are the same circumstances when the error in using it is greatest. We recommend that practitioners should be wary of using modified Poisson regression to approximate risk and relative risk.
Confidence Intervals for the Relative Risk
Authored by Michail Tsagris
Confidence interval for the ratio of two independent binomial proportions is an important measure, especially in medicine. The relative risk is such an example where accurate interval estimation is crucial. In this work we compare 4 different methods for the construction of such intervals. Simulation studies using many combinations of the sample sizes and of the true proportions reveal interesting conclusions as to the suitability of either method.
Relationship of Gelatynase B Enzyme Activity and Coronary Artery Disease
Authored by Aysegul Bayramoglu
Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of atherosclerosis, the pathology underlying the majority of coronary artery disease (CAD). We planned to investigate the association of enzyme activities of gelatinase B (or matrix metalloproteinase-9) in CAD patients. For this reason,102 patients with CAD and 99 control group recruited in this study. Serum gelatinase B enzyme level determinated from these peripheral blood samples by using Enzyme-Linked Immunosorbent Assay (ELISA). The results were evaluated by using statistical analyses. The level of gelatinase B increased in patients according to control group. As a result of our study, serum gelatinase B level was associated with CAD and could be used as a clinical marker.
To read more.... Fulltext in Biostatistics and Biometrics Open Access Journal in Juniper publishers
Book Review ‘Rahsia Dan Imej Wanita’ (Malay Version)
Authored By Uqbah Iqbal
Written by Ghafar Nin and Merina Haji Ibrahim, this book states that a healthy body is a requirement for active women.The creators of the comet have long been utilizing natural plants for body care.
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