Friday, October 9, 2026

A Therapeutic Yoga Program for University Students with Anxiety: A Mixed Methods Study - Juniper Publishers

 

Yoga and Physiotherapy - Juniper Publishers

Abstract

Anxiety remains one of the most common mental health disorders in the United States. Many university’s students report having a high level of anxiety, with additional life stressors that might include being away from home for the first time, being around unfamiliar people, having new expectations placed on them, and often have financial struggles. Universities have the ability and opportunity to form programs that can involve students with activities that reduce stress and teach coping skills. This research includes one example of using a therapeutic yoga class to teach these skills and assist students in applying these strategies to their daily lives. This study compared a group of 17 students participating in weekly yoga classes to 34 students who did not attend the program. The students who attended the program reported a larger reduction of anxiety on both the Beck Anxiety Inventory and Generalized Anxiety Disorder 7-Item Scale than the control group, and verbally reported additional benefits in relaxation and coping skills.

Keywords: Anxiety; Yoga; Therapeutic yoga; Students

Abbreviations: BAI: Beck Anxiety Inventory; IRB: Institutional Review Board; GAD-7: Generalized Anxiety Disorder 7

Introduction

Anxiety and stress-related issues are on the rise in the United States, particularly among young adults [1]. While the DSM-5 states that the diagnosable 12-month prevalence for Generalized Anxiety Disorder is 2.9% among adults, with a lifetime risk of 9.0% [2], it does appear that rates of anxiety are particularly high and growing in the 18-25-year-old age range. In addition, non- diagnosable anxiety or high levels of stress can cause a great deal of distress to individuals. For example, there is a high number of medical visits and medications specifically related to anxiety or stress related issues. Up to 70% of medical visits may be for challenges related to stress [3]. Today’s university students report high levels of anxiety and other mental health challenges. These students are often during a high number of life changes. They may be away from home for the first time, may be exposed to new people and new cultures, have new expectations being placed on them, and may have the financial stressors associated with attending college with little time for employment [4]. Students may also experience performance anxiety in the classroom such as test anxiety and in internships [5], which can challenge their ability to learn [6]. explored issues around stress and anxiety in social work students. They found that first year and final year students had particularly high levels of stress and anxiety. It may be that students who are adjusting to their new roles at university and students who are preparing to graduate and who may have anxiety relating to leaving school and finding work may have particularly high needs. A significant number of college students are seeking help for mental health issues. As we are in the second full year of COVID-19, it is likely that the long-term stress of living in a pandemic may have caused some of these mental health challenges to increase in the student population. One study showed that early in the COVID-19 pandemic, individuals aged 18-24 experienced stress, anxiety, and depression. This study reported signs of anxiety in adults to be 50.9%, and signs of stress to be at 57.4% [7]. In addition to students reporting isolation and lack of interaction, financial concerns, challenges with online classes and technology issues, and an overall sense of fear and insecurity, Gupta and Agrawal (2021) found that students who already have mental health concerns report an aggravated level of both anxiety and depression during this pandemic [8].

Unfortunately, many students who have mental health needs do not obtain services Elbert et al. [9] completed a cross-national survey that showed that less than one in four students who have needs seek and obtain treatment. There are significant barriers to students obtaining mental health services that may be able to assist them with anxiety or other mental health challenges. Many university students may be unaware of formal mental health supports such as counseling or are not willing or not able to make use of these services. Mental health services may be difficult to obtain, even for students who would like to attend counseling. Financial strains, long wait times to get in to see a campus therapist, or the low number of sessions offered by many universities may be barriers to formal counseling services [10]. Even if resources are available and the students are aware of them, the stigma attached to utilizing the services can keep students from being willing to use them. Students report that they prefer to try to handle their problems on their own [11]. The perception that help is not needed and constraints around time are also cited as reasons for not obtaining services Ennis et al. [12]. There are a variety of clinical strategies that may be implemented to assist individuals in coping with anxiety. Traditional talk-based psychotherapy, sometimes combined with the use of medication, is often used for anxiety and other mental health challenges that college students may face [13]. Common forms of psychotherapy may include Cognitive Behavioral Therapy [14], Acceptance and Commitment Therapy [15,16], and Exposure Therapy [17]. These treatments are evidence-based practices used by clinicians across the United States. Yoga and mindfulness techniques have also emerged as beneficial treatments in more recent years [18]. Most forms of exercise have benefits on both physical and mental health, including anxiety disorders. Yoga as a physical exercise may reduce anxiety and stress. Yoga classes are typically offered at gyms and yoga studios and typically focus on helping participants practice this physical exercise in a safe way. However, yoga can also be incorporated into mental health treatment, typically as an adjunctive treatment for an individual who is also in therapy. When therapeutic yoga is used as an adjunctive treatment, the focus is on assisting the client in finding relief from specific symptoms. The yoga therapist will assess the client and implement an appropriate therapeutic yoga intervention. This may be in either individual or group sessions.

Studies have shown that yoga as an exercise as well as therapeutic yoga can be an effective tool in reducing symptoms of mental health disorders for many people. Gladden et al. [20] noted that students in a six-week therapeutic yoga class had a variety of positive impacts on the participants, particularly in the areas of self-care, embodiment, and mood. Harkess et al. [21] conducted a study implementing a 16- session, 8-week yoga class to mostly middle-aged women who generally worked in professional settings. The researchers’ findings demonstrated that participants in the study had overall improvements in positive affect, decreased levels of psychological distress and perceived stress. Hofmann et al. [22] completed a meta-analysis on the impact of yoga on anxiety, and explored the data provided by 17 different studies (n=501). This meta-analysis showed two important factors: that the efficacy of the use of yoga was associated with the amount of time spent practicing yoga, and that people with elevated levels of anxiety benefited the most. Similar studies have shown positive results of yoga on stress and anxiety. There are few studies that examine the use of yoga for university students. The preliminary evidence shows that yoga may have positive results on the mental health of university students, particularly for issues relating to anxiety and stress [23]. Godse et al. [24] conducted research in Pune, India to study the effects yoga on college students. The students’ age ranged from 17-22 and had reported experiencing high levels of stress. The study concluded that the use of yoga reduced students’ stress, increased mental calmness and joy, as well as reduced sleepiness, worry and negative emotions. Kim [25] conducted a study with undergraduate nursing students and the effects of yoga on stress. In this study, life stress was measured by the Life Stress Scale for college students. It was found that the Life Stress Score significantly differed between the control and intervention groups. For the yoga group, post- Life Stress Score was significantly decreased compared with the mean pre-Life Stress Score. The control group reported an increase in their stress levels. This study continues to lend data towards the benefit of yoga for college students in reducing the stress and anxiety they are experiencing. Similarly, [26] explored the use of yoga within a college class and found that yoga can assist college students in slowing down and gaining greater ability to deal with busy lives. This research study was conducted to explore the effects of a therapeutic yoga class on students’ perceived levels of anxiety. The previous studies discussed on yoga for college students appeared to be primarily focused on the impact of a nontherapeutic yoga class, which is primarily a form of exercise. A therapeutic yoga class is typically conducted in a different manner than a therapeutic class that is specifically created for groups who have anxiety of other mental health diagnoses or challenges [27]. We hoped to discover whether the therapeutic yoga classes were able to reduce the students’ levels of stress and anxiety, and to hear from the students in their own words how the experience may have been helpful to them.

Materials and Methods

This research uses a merging data mixed methods design to combine quantitative data from pre- and post- surveys with the data from several focus groups to explore the students’ own words and reported experiences, as recommended by Creswell et al. [28]. Our research questions included: 1. Is there a difference in changes of scores from the Beck Anxiety Inventory (BAI) and Generalized Anxiety Disorder 7-Item Scale (GAD-7) between the intervention and control groups?, 2. What impact do the students in the intervention group report the therapeutic style yoga classes had on their perceived anxiety or on other parts of their life?, and 3. How can the reports from the students in the focus groups help the researchers understand any changes in the BAI and GAD-7 scores? This research was conducted as a pilot study with the hopes of offering continued services to the students if the results indicated a positive impact. The researchers completed all required steps from the university before beginning the study, which included receiving the Institutional Review Board (IRB) approval. Any registered student was eligible to participate, including undergraduate and graduate levels. Recruitment for the therapeutic yoga class intervention was through email, flyers on campus, and announcements in classes when possible. Students were requested to pay a $25 fee for the series to encourage commitment, however ‘scholarships ‘or fee waivers were offered and provided to any student who cited cost as a barrier. Funds collected were used towards paying for the room for the class. No students were turned away from participating in the yoga intervention. The class was offered at several locations on campus, including the fitness center and a community center. Seventeen students, primarily undergraduate students at the sophomore and junior levels, completed the intervention. All the participating students identified as female. Thirty-four undergraduate students completed the pre- and post- tests for the anxiety scales. These students identified as both male and female. The participants in the therapeutic yoga intervention completed a pre-survey questionnaire to identify the levels of previous engagement in yoga, physical limitations, and goals for taking the yoga class. The intervention group and a control group made up of students in two university classes who chose not to participate in the therapeutic yoga series completed the Beck Anxiety Inventory (BAI) and the Generalized Anxiety Disorder 7-Item (GAD-7) scales at the beginning and end of the yoga series, which roughly corresponded with approximately week 5 and the week before finals in the semester. In addition to the completing these scales, several focus groups of made of up individuals who completed the therapeutic yoga series intervention were completed to provide the students’ own perspectives on the intervention and its impact on their anxiety as well as other areas of their lives. The combination of scores from reliable anxiety scales and the participants own words on their experience was designed to provide a deeper level of understanding on the impact of the intervention. Data analysis included the comparison of quantitative scores from the BAI and GAD-7 in the intervention and control group. An excel spreadsheet was created comparing the two groups and their changes in scores. In addition, all data from focus groups was recorded and transcribed, then analyzed by hand for similar themes.

The results from the control group concluded that the students had the slightest decrease in anxiety scores from the beginning to the end of the intervention time period based on the two measurement tools. The GAD-7 showed that the control group scores had decreased by an average 10% from the pre-test. Out of the 34 control group students, only ten students showed a decrease in scores ranging from 5% to 100%. The majority of the ten students showed a decrease in score for “relax” and “worry.” For 24 students their post scores either stayed the same or increased from 1%-10%. Out of the 24 who did have increased anxiety their scores for feeling “afraid” increased by 1%. Even though the average score had decreased by 10%, more students’ scores increased then decreased. The control group’s BAI posttest showed an average 4% decrease from the pre-test. Out of 34 students, only 12 showed a decrease in scores. Of the 12 students who had decreased scores, 91% decreased in having sweats, 75% decreased in having trouble relaxing, and 66% decreased in trembling. The remainder of the 22 people who had an increased in scores; 64% had an increase in feeling wobbly, and 45% had an increase in feeling relaxed, heart rate, being unsteady, and feeling terrified. Both the Gad-7 and BAI for the control group showed a decrease in the score, but the focus group resulted in a greater decreased score.

The results for the intervention group concluded that the students had decreased scores on both the measurement tools. On average the intervention group decreased by 35% from the GAD-7 test pre-test. Two people post-tests increased by 2%, with increases in the areas of “worrying too much” and “afraid.” Each of these students reported having major life changes that resulted in their increase in worry and fear. Out of 17 students, 15 students had decreased scores. Each of these 15 students’ scores decreased in “easily annoyed,” and 80% scores decreased in feeling “nervousness.” The intervention group showed a 25% difference between the decrease in scores for the GAD-7 control group post-test. For the intervention group, the BAI post-test showed an average 45% decrease from the pretest. There were three people who score had increased by 1%. The scores increased by two points on “feeling hot,” “dizzy,” “unsteady,” “scared,” and three points on “having sweats.” The remainder of the 14 students’ scores had decreased. 100% decreased in their report of “heart rate” and “nervousness,” 78% decreased in “losing control,” and 71% decreased in “trouble with relaxing.” The focus group showed a 41% difference between the decrease in scores for the BAI control group posttest. Thus, our first research question, is there a difference in changes of scores from the Beck Anxiety Inventory (BAI) and Generalized Anxiety Disorder 7-Item Scale (GAD-7) between the intervention and control groups? was answered. There is a distinct difference in scores between the two groups. The small size of the sample discouraged analytical statistics to determine if this difference was significant, so we then turned to our second research question. The transcription of the open dialogue between instructor and students at the end of the semester also provided valuable information, helping to answer the second and third research questions, “What impact do the students in the intervention group report the therapeutic style yoga classes had on their perceived anxiety or on other parts of their life?, and “How can the reports from the students in the focus groups help the researchers understand any changes in the BAI and GAD-7 scores?” At the beginning of the dialogue, the yoga therapist asked the students what had motivated them to complete the yoga class for the entire semester. All students reported it being “helpful.” Specifically, one student reported, “I knew it was good for me because I felt it during the whole week, at least during the day of our yoga on Tuesday. I just felt like, relaxed the whole day and kind of grounded and ready for the day”. Students also indicated it was more helpful during the end of the semester, stating the stress levels increase with the amount of work at the end of the semester. They stated yoga was a way to relax from that stress, at least during the period of the class.

Furthermore, the yoga therapist asked the students if they found that participating in the yoga class had helped with anxiety and being able to relax. All students indicated they found it helpful. One student specified they were not only able to find it helpful during class but had also started implemented it in other areas of their week such as in other classes and at their internship. One student stated, “I feel it did help. I mean I had recent events that it just increased my anxiety. Like all the time, but I mean I feel like it would have been worse if I wasn’t doing yoga. So, I do feel like it helped even in just like a little bit so definitely for sure”. It was also reported there were additional benefits from participating in the yoga class, such as physical strength and learning to cope ahead for stressful situations. Specifically, a student reported, “It also helped me build my upper body strength, and I felt stronger not just my body, but my mind also felt stronger, and I was able to calm myself. If I felt the anxiety come, I’d just start doing some deep breathing or child pose in class. I’ve done that a couple of times”. The students specified being “more focused” and practicing “better self-care.” One student described taking time to put themselves first, instead of putting other people needs in front of their own. Another student reported they felt more comfortable in public, crowded areas and found themselves interacting more with others than they had in the past. Additionally, the yoga therapist asked the students if they noticed any significant changes after each yoga class relating to their anxiety. Each of the students reported they noticed changes that were helpful. One student stated, “I just felt much more grounded and calmer”, and “I was able to control my emotions where usually my anxiety feels out of control. But with yoga, I was able to control my breathing and control what was happening to me”. Another student stated, “Tuesdays are my busiest days, but after yoga, I was able to focus.”

The overall results of the study proved positive. Although both the focus and control group had a decrease in scores on each scale, the focus group had significantly decreased symptoms. Although not every student participating in the focus group had a reduction of anxiety symptoms, 15 of the 17 students had decreased symptoms. Two students reported a change in life events that contributed to their higher scores, even though they reported that the classes were helpful to them. The control group showed that students without the intervention of yoga had minimal symptom reduction. The open dialogue with the students showed positive results across the board. The students as a whole felt the yoga class was helpful and was useful in reducing anxiety and increasing focus and self-care.

Discussion

Anxiety has become widespread throughout the United States. Thousands of people struggle with symptoms of anxiety daily. There have been many coping methods implemented in clinical practice to assist individuals who are coping or struggling to cope, with anxiety. Researchers and clinicians have sought to find more effective methods to assist these individuals. Methods that have been adopted to assist with anxiety include yoga and therapeutic yoga. As the research shows, yoga and therapeutic yoga has benefited many people who struggle with stress and anxiety. University students are among this population of people. This research has indicated the vast benefits yoga can provide to these students, including increased physical health benefits, decreased stress, and increasing the ability to focus and care for oneself. Stress and anxiety tend to rise among college students toward the end of the semester. If students cannot find healthy ways to cope with stress and anxiety, their symptoms may increase. This was shown in the difference between the overall scores of the control group and intervention group in this study. The intervention group participated in a therapeutic yoga series, which helped them cope with stress and anxiety in a health manner, leading to overall scores on GAD-7 and BAI that either decreased or remained the same. The control group did not participate in the yoga class, as participants overall reported an increase in anxiety symptoms. Although the results were limited in this study, which may influence the reliability of the data, there was still valuable information obtained. Although the intervention group was half the size of the control group, the results showed a higher decrease in anxiety symptoms in the intervention group compared to the control group. The control group had no known interventions implemented in the study to assist in coping with their anxiety symptoms. It should be considered the timing of the post-test as it was the end of the semester and students had an increase of stress due to exams and projects or a decrease in stress because they have already finished the assignments. This indicates that students who did utilize therapeutic yoga as an intervention benefited by either reducing anxiety or remaining the same. Another contributing factor to the intervention group results may come from the indication that they not only participated in the therapeutic yoga class but also started implementing the techniques into everyday life. The literature and research in this study both show positive results for college students who utilize yoga as a coping tool to help deal with the symptoms of anxiety. Although the number of students who participated limited the intervention groups results, there does appear to be some evidence to show that the yoga class did have positive outcomes for the participants. This was proven through the data collected from the GAD-7 and the BAI, as well as the open dialogue between instructor and students. As clinicians strive to find the most effective treatments for anxiety, therapeutic yoga is certainly emerging as a potentially encouraging option.

The use of exercise-based yoga classes or therapeutic yoga classes may be a viable option to help reduce anxiety in college students. Many of the barriers that student report regarding formal mental health supports such as psychotherapy may not be a concern for yoga. Yoga classes or therapeutic yoga classes typically do not hold the same kind of stigma that therapy has. Students may be less fearful of what others think about their attendance in a yoga class. The cost of offering these classes is likely less than the cost of providing therapy through a campus counseling program and could reach a higher number of students. While time and transportation could continue to be barriers, offering classes on campus and in a variety of location could at least partially reduce this barrier.

Limitations

There are limitations to this research. As the research targeted a population of students with many other obligations, the sample size was minimal. As college students have busy schedules and busy lives, many different factors may have interfered with their attendance and completion of the yoga class. Noting there was a small sample of participants, the researchers analyzed the data to reflect the most useful information, with a focus on the qualitative discussion. The limitations also include the lack of diversity within the sample. As this college’s population is primarily lower to middle class students who overwhelmingly identify as Caucasian, both the intervention and control group participants’ identities were similarly narrow. We are not able to generalize this data to other identity groups. In addition, most participants were undergraduate students, with few graduate level students and no doctoral level students. Researcher risk of bias is also a limitation. The yoga therapist/ primary researcher identifies as a middleclass Caucasian cis-gender heterosexual female. In addition, each of the graduate level student researchers identified as Caucasian cis-gender heterosexual females. The lack of diversity in the researchers’ identities may impact the perspectives from which the data was analyzed. Ethical issues to be considered include the yoga therapist and researchers’ roles in the yoga class. As the researchers are part of the student body and faculty of the university where the study took place, there was the possibility that participants might have felt obligated to complete the course and the surveys. To avoid these issues, the participants completed a consent form, which informed that their participation in the yoga class or research would not affect their grade or status as a student. The data was also collected anonymously and held in a secure area to prevent any breaches of confidentiality. No names were used on the pre- and post- tests, as students self- selected a code name. Names were not transcribed during the focus group after the yoga series was complete, although the researchers were present to complete the focus groups.

Implications for practice and research

The results of this study, along with other literature in this area, have shown at least preliminary positive results on the use of yoga and therapeutic yoga to reduce anxiety in university students. This intervention may be particularly useful for students who are unwilling or unable to attend psychotherapy sessions, due to the stigma or other constraints. While many colleges and universities offer yoga classes as a part of their curriculum, having additional classes offered outside of for-credit courses could be highly beneficial. These services could also be a cost-effective way of providing support for students. The group format and the cost of hiring a trained yoga instructor or yoga therapist (particularly compared to the cost of hiring additional psychotherapists) may reduce the overall cost of providing services for students. If students were able to access services to reduce their anxiety and stress, they may be able to increase their performance in their coursework. In addition, reducing anxiety may be able to prevent students from dropping out due to these mental health issues and increase the retention and graduation rates for the university. Further research in this area is indicated. While there is evidence to support that both yoga as an exercise class and therapeutic yoga can reduce anxiety in university students and other populations, there is not yet enough information to provide specifics regarding various formats of yoga and how many classes are needed to provide support for positive change. Studies vary in the number of weeks the courses are, and how many times a week they meet, in addition to the types of yoga used. Each of these areas should be explored to provide the best options for student mental health support. It could be particularly important to determine if yoga exercise classes are sufficient to reduce anxiety, or whether a trained yoga therapist providing therapeutic yoga classes might increase the positive results. In addition, much of the research in the United States has either not reported on the demographics of the research or the students are reported to overwhelmingly identify as Caucasian. No research was found on the effectiveness of yoga for students who identify as individuals of color. Research has shown that there may be barriers to participating in yoga for individuals of color [29], so this area should be explored in further research. Similarly, it is not known whether other oppressed identities, such as gender or sexual identities, may impact an individual’s participation in or experience of yoga in this setting. These areas should also be explored to determine if this intervention can be accessed in an equitable manner for all students.

Conclusion

Previous research has shown both yoga and therapeutic yoga to be effective interventions in assisting individuals to cope with anxiety and stress. This specific study sought to learn how therapeutic yoga may impact college students who experience anxiety. The findings showed overall positive results for the focus group compared to the control group in the study. Universities should consider adding interventions such as yoga and therapeutic yoga to their campus programing to reduce the barriers in providing support for students who may be experiencing anxiety and stress.

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Wednesday, October 7, 2026

How Does the Multi-Disciplinary Team Impact Chronic Kidney Disease Management? - Juniper Publishers

 

Urology & Nephrology - Juniper Publishers

Abstract

Chronic kidney disease (CKD) is a condition where a gradual kidney function loss leads to a build-up of toxic waste products in the blood, increasing morbidity and premature deaths from enhanced risks of cardiovascular disease, stroke and mineral bone diseases. The most common causes of CKD include type II diabetes and hypertension, both accounting for two-thirds of all cases. CKD is asymptomatic in early stages and is only diagnosed via routine screening tests unless severe symptoms arise from advanced CKD. Management of CKD via multidisciplinary team (MDT) consisting of professionals from various disciplines has been hailed as the best modality in treating such a multi-faceted chronic disease, leading to positive impacts on patients’ experience and clinical outcomes.

Introduction

More than 1.8 million people are diagnosed with CKD in England [1] where the advancing age is commonly associated with the higher incidence of CKD stage 3-5. Figure 1 is an illustration that on average, whilst there is only an estimation of 1.9% of the population having moderate to severe CKD, that figure is increased to 32.7% for those aged 75 and over. The latest guideline established that NHS England spent £1.45 billion in 2009-10 attributing to £1 in every £77 spent by NHS in managing CKD and associated illnesses stemmed from the condition [1]. Progression patterns and risk factors of CKD into end-stage kidney disease (ESKD) can be established well before the need to initiate renal replacement therapy (RRT). Therefore, proactive intervention strategies to prevent its progression form a basis of management of CKD which is mainly delivered via a multi-disciplinary team (MDT) to address all the various aspects and risk factors of CKD. This paper aims to explore and describe how effective this MDT approach is in treating CKD.


Chronic Kidney Disease (CKD)

Chronic kidney disease (CKD) is a multi-factorial disease leading to progressive worsening of kidney functions. Kidney biopsies from most CKD patients will often show glomerulosclerosis, tubular atrophy and interstitial fibrosis. Moreover, at the end stage of kidney failure, they will feature a characteristic renal fibrosis where the kidney undergoes unsuccessful wound healing after chronic and sustained inflammation and injury to its tissues. CKD can be classified into 5 stages based on an estimated glomerular filtration rate (eGFR) which represents the amount of fluid each functioning unit (nephron) of kidneys filters through, per unit time. Figure 2 demonstrates the progression of CKD in stages using eGFR and albumin to creatinine (ACR) ratios [2]. A consistently high level of kidney disease markers (illustrated in Table 1) over a period of 3 months and a GFR at G3 stage are two criteria that need to be met in diagnosing CKD. G5 of GFR is termed as end-stage kidney disease (ESKD) where failure of kidney can only be managed with renal replacement therapy (RRT) including dialysis or kidney transplant unless the patient wishes to undergo conservative management.



Causes and Prevalence of CKD

Exact aetiology of CKD is not fully understood; however, older age, type II diabetes, and hypertension are associated with diabetic glomerulosclerosis and hypertensive nephrosclerosis both leading to CKD in Western world [3]. Main causes of CKD in developing countries include glomerular and tubulointerstitial diseases due to infections, drug and toxin exposure. A small percentage of CKDs also arises from congenital conditions such as polycystic kidney disease. Gender difference plays a role in CKD with males showing a more rapid and aggressive CKD progression, suggesting the potential roles of sex hormones in modulating synthesis of growth factors and chemical mediators leading to CKD progression [4]. Ethnicity and socioeconomic status are also key modifiers in CKD prevalence and progression. There is a 60% increased risk of worsening CKD in people of the lowest social quartile when compared with their richer counterparts. This progression is highest in people with ethnic minority backgrounds and can be attributed to having reduced medical awareness and access to specialist nephrologist care in both pre-dialysis and dialysis groups [5].

Clinical Presentation and Complications of CKD

CKD is non-symptomatic in the earlier stages and most diagnoses are made via routine tests unless patients present with severe symptoms from advanced CKD. As the kidney gradually loses its function from progressive disease, there is a rapid accumulation of uraemic retention solutes in the body which can then affect various parts of the body. Uraemic toxicity can lead to vascular damage increasing the risk of cardiovascular diseases and bleeding episodes, impaired inflammatory and immune responses, and altered microflora in the digestive system [6]. Impairment to normal kidney functions can lead to proteinuria, oedema, hypertension, hyperphosphatemia, hyperkalaemia, anaemia and bleeding diathesis, renal osteodystrophy, congestive heart failure, gastrointestinal disturbances and generalised myopathy [7].

Multi-Disciplinary Team in Management of CKD

With medication compliance and adequate lifestyle changes including keeping a normal weight, taking up exercise and following a renal diet, CKD patients can remain as healthy as possible. Management plan is aimed to treat primary pathological diagnosis along with an intervention based on eGFR stages and albuminuria to control hypertension, diabetes, dyslipidaemia and anaemia to prevent episodes of acute kidney injury (AKI) and reduce its complications. A referral to nephrology is to be initiated when patients with poorly controlled hypertension even after treatment with at least 4 anti-hypertensive drugs, reach either G4 or G5 stage with decreasing GFR of less than 30ml/min/1.73m2 and an ACR of 10mg/mmol or higher [8].

A typical renal department provides inpatient and outpatient services covering general nephrology, pre- and post-dialysis review, low clearance clinics and transplant follow-up. The department is made up of a team of professionals from various disciplines including consultant nephrologists, clinical nurse specialists (CNS) and dieticians. Joint clinics are typically run in parallel with endocrinologists for diabetic patients with CKD, with cardiologists to manage their cardiovascular health and lastly with rheumatologists for patients with hyperuricemia to manage their gout and joint pain associated with CKD.

In addition, a team of MDT managing CKD also includes surgeons working together with interventional radiologists to get an intravenous line in or to form fistulae for good vascular access for dialysis. Interventional radiologists are valuable for the team since they can also perform other key procedures such as image-guided percutaneous renal biopsy allowing the clinicians to treat the underlying causes. In addition, the maintenance of fistulae and veins which allows good vascular access for future dialysis is relied upon the great effort of vascular access CNS who work alongside surgeons and radiologists to support the patients regarding fistulae care.

Role of MDT in Management of CKD

Anti-Hypertensive Therapy

There is a 57% increased mortality from cardiovascular causes when patients reach a GFR of less than 60mL/min per 1.73m2 [9]. In addition, CKD patients have 5-10-fold increased risks of dying from other complications than progress into ESKD [10]. Keith [11], also published results from a longitudinal study which concluded that CKD patients are twice likely to die from CVD complications than develop ESKD. Therefore, one of the roles of the consultant nephrologist is to prescribe anti-hypertensives accordingly, and to monitor patients’ blood pressure and other side effects arising from these therapies. Antagonists of reninangiotensin- aldosterone system such as angiotensin convertingenzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) are first-line choice of agents in CKD patients to reduce proteinuria which is the main culprit for disease progression [12]. However, ARBs and ACEIs can also lead to hyperkalaemia in CKD patients and therefore should be continuously monitored for their blood potassium levels.

Management of Anaemia

One of the main functions of kidney is to produce erythropoietin (EPO) which is a hormone stimulating red blood cell production. CKD patients typically present with hypo proliferative, normocytic, and normochromic anaemia due to impaired EPO production by the kidneys. CKD patients often have chronic anaemia which reduces patients’ quality of life and puts them at higher risks of deaths. There is a 29% increased chance of hospitalisation in patients with haemoglobin (Hb) of <10 g/dl than those with Hb between 11-12 g/dl [13]. Therefore, iron and derivatives of recombinant erythropoietin are commonly used in treatment of anaemia, decreasing the need to transfuse blood [14]. Chronic anaemia is normally managed by anaemia CNS who monitor patients’ iron levels and administer intravenous iron and erythrocyte-stimulating agents (ESAs) to the patients, as prescribed by the nephrologists. They are also important in providing counselling sessions for pre-dialysis and dialysis patients informing them of local and national treatment guidelines to help decide their future treatment plan.

Management of CKD Mineral Bone Disease and Gout

The kidneys regulate how calcium and phosphate are absorbed in the intestine by regulating vitamin-D metabolism which converts vitamin-D to calcitriol (activated vitamin D). CKD patients can have abnormal serum concentrations of calcium, phosphates and reduced calcitriol levels, leading to pain in the bone or bone fragility due to increased osteoclast activity. Management of CKD mineral bone diseases include renal diets restricting phosphates and prescription of calcium or non-calcium phosphate-binders and activated vitamin D in those with low serum calcitriol levels (>30 ng/mL) and normal parathyroid hormone levels [2]. In addition, CKD patients often have high uric acid level (hyperuricemia) which can lead to acute or chronic gout attacks for which uric acid lowering agents such as allopurinol and febuxostat are used to manage hyperuricemia. Therefore, it is the role of the renal dieticians to offer guidance on which food to avoid and how to prepare an adequate meal for good renal health, along with offering support and help to lose weight, exercise more and quit smoking, if need be.

Renal Replacement Therapy (RRT)

There is no universal definition or endpoint of CKD at which ESKD can be diagnosed and renal replacement therapy (RRT) is to be established since patients can have differing levels of comorbidities. When the patients’ eGFRs start to approach 15%, they are consulted to discuss and make timely arrangement for further treatment plans including starting dialysis (either peritoneal or haemodialysis), kidney transplant or undertaking conservative treatment. However, a study supported by USA National Kidney Foundation concluded that an acceptable surrogate endpoint should be when a decrease of eGFR of 30- 40% within 2-3 years excluding causes of acute kidney injury (AKI) [15]. Generally, GFR of less than 15mL/min/1.73m2 along with presentation of uraemic symptoms can warrant a consultation of RRT which involves either dialysis or kidney transplantation.

RRT takes up a huge portion of NHS kidney budget and there was an estimated total annual cost for both haemodialysis and peritoneal dialysis of £505 million and a total annual cost for all transplants was reported to be £225 million in 2009-2010 [1]. Having a strong MDT team behind the patients makes an important difference to ESKD patients regarding making lifechanging decisions when considering RRT. There is a huge burden for patients to consider whether to enlist for RRT or undergo conservative management. A randomised control study carried out by Cooper et. al., in Australia and New Zealand in 2010 (IDEAL study) did not find any difference or improvement in survival outcomes and mortality rates when stage V CKD patients were started on early or late dialytic treatments. Therefore, it is paramount that a patient needs to be educated and consulted on optimal timing of initiating dialysis, which modality of dialysis to choose, extent of time waiting for the matched donor kidney for transplantation and how to cope with immunosuppressants and post-transplant complications.

Overall Impact of MDT in CKD

Incorporation of MDT in CKD care has been supported widely due to its positive outcomes from several studies published over the years. A study by Lin [16], published in PLoS, found that MDT increased quality of life adjusted years (QALYs) by 0.23 per person, when compared with non-MDT care. Cost-effectiveness of MDT has also been reported where MDT care leads to a reduction of $1931 annually per patient from reduced RRT and emergent need for dialysis since MDT was shown to slow eGFR decline and infection-specific hospitalisation [17].

Furthermore, a prospective study led by Chen [18] in Taiwan, also reported that patients under MDT care had a 51% reduced mortality than patients under usual non-MDT care. Moreover, a holistic approach provided via MDT care ensures that one will be guaranteed with an individualised and targeted management plan including health education and awareness of nephrotoxic nonsteroidal anti-inflammatory drugs (NSAIDs) which are contraindicated in CKD patients since they can lead to severe renal injury and progression of CKD [19].

Summary

To conclude, CKD is a chronic disease associated with multiple co-morbidities. To manage such a multi-faceted disease accordingly, only a multi-disciplinary team with professionals working towards the same goals and acting in the best interests of patients, will be able to improve patients’ quality of life and bring positive clinical outcomes. As CKD progresses, there is a need for a more collaborative effort between members of the MDT to address the increasing needs of the patients as they present with more complications. However, integration of such collaborative works may also need enhanced communication between colleagues to provide optimal care for the patients. Although effectiveness of providing a more integrated care via MDT has been established, determination of one optimal professional in an MDT has not been elucidated yet, requiring more randomised studies to follow [20-22].

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Tuesday, September 29, 2026

Efficacy of Prostaglandin Analogues for Induction of Labour and Associated Complications: A Retrospective Research Study conducted in Latifa Women and Children Hospital - Juniper Publishers

 

Reproductive Medicine - Juniper Publishers

Introduction

Induction of labour has become a more common worldwide medical intervention during the last few years [1]. The ideal cervical ripening agent must be effective, safe, easy to be administered and acceptable for the pregnant woman. Utilizing prostaglandins (PG) for cervical ripening during induction of labour (IOL) was first described in the 1960s [2]. Since that time various types of prostaglandins including PGF2α, PGE2 (Dinoprostone) and PGE1 (Misoprostol) were extensively studied to elicit the best prostaglandin pharmacological agent for pre-induction cervical ripening [2]. Dinoprostone was found to be superior to the others, as it increased the rates of successful vaginal delivery within 24 h without increasing the operative delivery rates. Vaginal route was found to be a safe and effective approach of bringing on labor.2

There are different pharmacological and mechanical methods that have been approved to ripen the unfavourable cervix [3]. Prostaglandins are the most effective drugs that cause cervical ripening by increasing inflammatory mediators in the cervix and inducing cervical changes. Prostaglandin E1 (PGE1) and prostaglandin E2 (PGE2) have different effects on these processes and on myometrium contractility [4]. The PGE2 is available for cervical ripening as a 3mg Dinoprostone vaginal pessary and also as a controlled release pessary (Propess®), which releases 10 mg of Dinoprostone over 24 hours. Prostin tablet is inserted into the vagina every 6 hours, with a maximum of 3 doses, as per our hospital protocol.

The effect of PGE2 has been investigated and there are many studies in the literature comparing the efficacy of the different formulations available in the market [5]. The incidence of Induction of labour is rising in the current era, with the advancement of technology viz. increasing frequency of ultrasound studies and CTG for fetal monitoring and assessment of fetal wellbeing by fetal medicine units. An appropriate and well tolerated pharmacological method of induction of labour cannot be decided without doing a detailed and in-depth analysis of the two commonly used drugs.

This research study was conducted to compare the efficacy of Propess and Prostin for induction of labor and their complications according to national and international standards.

Therefore, it will help us to update the current hospital guideline of Induction of Labour and eventually improve patient care.

Methodology

This is a retrospective study conducted over a period of 6 months from 1/10/2019 to 31/3/2020. The data was analysed from 597 patients in Latifa Hospital, Dubai, United Arab Emirates for the period of 12 months (1/10/2019 to 30/9/2020). The efficacy of two drugs Prostin and Propess, for induction of labour were compared with respect to their progression to labour and associated complications. The data was collected from the labour room records. Inclusion criteria included pregnant females that were 18-45 years old, gestational age of 28 weeks or more, singleton pregnancy, and cephalic presentation. Exclusion criteria included previous caesarean section/uterine surgery, any contraindication to vaginal delivery, suspected cephalo-pelvicdisproportion, multiple pregnancy, and unexplained antepartum haemorrhage. The data was collected using MS excel sheet.

Demographics

A total of 622 patients were enrolled in this study. Complete data was available for 597 out of them. These were distributed into two groups according to whether Prostin (56.8%) or Propess (43.2%) was used for induction of labour (IOL). Variations between the two groups were accounted for in terms of the following demographic factors: age, gestational age, parity, and indications for IOL. The mean age of women who received Prostin in our study was 31.6 (SD 0.32) and this was higher than that of Propess which was 29.6 (SD 0.33). The gestational ages between both groups were rather similar with the mean of Prostin being 38.4 weeks (SD 0.10) and Propess was 38.6 weeks (SD 0.12). Nulliparity was the most common parity amongst our study group with a valid percent of 37.4%. This was double the incidence of the next common parity which was 1 (18.6%). A varied range of indications for IOL existed amongst these patients ranging across Medical (HTN, DM, Cholestasis of pregnancy etc) and Obstetric (post successful ECV for unstable lie, IUGR, post term, foetal demise). The common indications were Diabetes Mellitus (31.5%) followed by post term (10.2%) and followed by intrauterine growth restriction (9.7%).

Statistical Analysis

Numerical data are presented as mean ± standard deviation or median (min/max) as appropriate and categorical data are presented as a percentage. Chi squared test or Fischer’s exact test was used to compare categorical variables (viz. complications) between the two groups of the study. T-test or Mann-Whitney test was used to compare numerical variables between the two study groups as appropriate.

All the tests are 2-sided tests and P value <0.05 indicates statistically significant results. SPSS 24 was used for data analysis.

Efficacy of drugs

The efficacy of these drugs was assessed by whether labour started or not after induction of labour. It was shown that a total of 79.1% of women from both categories collectively progressed into labour while 20.9% did not. 81.4% of those who were induced with Prostin progressed to labour while 76.0% of those who were given Propess progressed into labor. Using the Pearson Chi-Squared test this had a p-value of 0.105(not significant). Reinduction, which is defined as multiple doses of prostaglandin, was required in 1.84% of our patient population.

Complications

The most common complications following IOL were nonreassuring cardiotocography (CTG) and hyperstimulation/ tachysystole. These had an overall occurrence of 90.3% and 8.2% for Prostaglandins respectively. Other complications such as abruptio placenta and postpartum haemorrhage (PPH) were not seen as frequently with a percentage of 0.5%. While comparing the drug used for IOL, non-reassuring CTG was seen in 10.9% in women who received Prostin while it occurred in 6.2% in women who received Propess. Hyperstimulation/tachysystole was seen in 1.2% of Propess patients while there were none that experienced it in Prostin patients. The Pearson chi-squared test analysing this correlation had a p-value of 0.024 (significant). The incidence of no complications was significantly common too, with 92.6% of those on Prostin having no complications and 87.2% of those with Propess similarly. Fisher’s exact test was used to analyse the above correlation resulting in a p-value of 0.011(significant). The mean age of those who had complications was found to be 28.76 years for both Prostin and Propess and mean parity for the same was 0.91 (SD 0.251). Median parity of those who had complications is nulliparity. Test used for this comparison was Mann-Whitney test with p-value <0.001 (significant).

Mode of delivery

Those that had normal vaginal delivery (NVD) were 78.9% of the study population whilst the remaining 21.1% delivered via lower segment caesarean section. Progression to normal vaginal delivery was more common in women who received Prostin (81.4%) compared to those who received Propess (75.6%). Pearson chi-squared test revealed a p-value of 0.084 (not significant).

Discussion

The present study compared the induction of labour using Prostin vs Propess through a retrospective analysis in the hospital setting. Prostin 3mg was administered 6 hourly vaginally up to 3 doses, whereas Propess (10mg) controlled release single pessary was administered vaginally and left in place for up to 24 hours. The success rates, which was defined as onset of labour, of Prostin and Propess were 81.4% and 76% respectively. This was not statistically significant (p value= 0.105). Following induction of labor with both the agents, the incidence of “reinduction” was rather insignificant and did not bear weight on the outcomes of our study. Many studies that have investigated the efficacy of prostaglandin E2 in the induction of labour showed that Propess had a higher success rate than Prostin [6,7]. A most recent study evaluated the effect of Dinoprostine vaginal insert (Propess) compared to that of the vaginal tablet (Prostin) in primigravida specifically [8], and showed that Propess was the preferred and a better tolerated Prostaglandin E2 tablet for IOL because of the reduced need for vaginal examinations. On the other hand, our analysis shows an insignificant difference in efficacy between the two Prostaglandins E2, which was the primary outcome in this study. This is supported by multiple randomised control trials that also showed no significant difference between the two groups resulting in no preference of one drug over the other in terms of better efficacy [9-11].

The secondary outcome, being the complications resulting between the two drugs, proved to be a non-reassuring CTG and hyperstimulation/tachysystole combined. In our research, nonreassuring CTG was shown in 10.9% of the Prostin cohort while 6.2% of the Propess cohort which is insignificant (p value= 0.084). A study done in 1992, supports our results by showing that non-reassuring CTG was similar in both PGE2 pessary vs placebo groups [12]. Tachysystole was defined as more than 5 contractions/10mins minutes for two consecutive 10-minute periods. Hyperstimulation is defined as either > 5 contractions in ten minutes over a 30minute period, or contractions lasting more than 2 minutes in duration, or contractions of normal duration occurring within 60 seconds of each other as written by the NHS Wales protocol. But many authors define Hyperstimulation as exaggerated uterine response with late fetal heart rate decelerations or fetal tachycardia of more than 160 beats per minute or other worrisome fetal heart rate changes [13,14]. Our results indicate that the combination group of hyperstimulation/ tachysystole was higher in the Propess cohort while none of the Prostin cohort experienced this complication (p value=0.0024). Similarly, the same comparison done in Walsall, UK resulted in more cases of tachysystole in Propess rather than Prostin [11]. Walsall also had a higher rate of uterine hyperstimulation in both prostaglandins compared with the placebo. However, in all the cases, hyperstimulation resolved within 15 min after removal of the pessary indicating that the direct cause was from the effect of the prostaglandins.

The complications in IOL among nulliparous women is greater than that in multiparous as shown in a 2020 study done in Ireland. Many nullipara (32.63%) had undergone caesarean section compared to the multipara (4.37%). Therefore, it is in conjunction with our results that nulliparous women had a greater number of complications in comparison to other parities within our study (p value<0.001). Moreover, previous studies show that induction of labour in medically uncomplicated nulliparous women at term carries higher risk of emergency Cesarean section, compared to those who underwent spontaneous labour [13]. However, our study showed an insignificant difference between the rate of NVD versus caesarean section in the IOL with Propess and Prostin collectively (p=0.084).

A limitation of our study included the lack of a control/ placebo group which could have been used for a more effective comparison.

Conclusion

The results of our study concluded that the success of inducing labour between Prostin and Propess is not statistically significant and either can be used for a favourable outcome. Complications following their viz. non-reassuring CTG, failure of induction, reinduction of labor, higher risk of emergency Cesarean section and are quite similar with both agents. However, tachysystole/ hyperstimulation was more with Propess. These complications, however, are greater seen in nulliparous women compared to multiparous.

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A Therapeutic Yoga Program for University Students with Anxiety: A Mixed Methods Study - Juniper Publishers

  Yoga and Physiotherapy - Juniper Publishers Abstract Anxiety remains one of the most common mental health disorders in the United States. ...