Friday, July 17, 2026

Adolescent Mental Health Care: Time for Revolution- Juniper Publishers

 

Journal of Case Studies- Juniper Publishers


Abstract

Compared to the mental health of adults, the mental health of young people is often disproportionately affected by disasters. The transitional phase from adolescence into young adulthood represents a window of opportunity to prevent new onset and to improve the outcomes of mental disorders. To a worldwide estimate, in the year 2020 between 10-20% of adolescents would have suffered from mental health problems for the first time. The main aim of this paper is to critically review the unmet needs necessary for developing integrated mental health services for adolescents and young people and to provide recommendations to be implemented in mental health services after the COVID-19 pandemic. The COVID-19 pandemic has been a global disaster that has affected the lives of adolescents and their families on multiple levels. Adolescents must receive the physical and mental care they need to develop, grow and enjoy a satisfying quality of life. Furthermore, both vertical, horizontal and longitudinal integration should be promoted.

Keywords: Youth mental health; Innovation; Mental health services; Integrated care; Multidisciplinary

Introduction

The COVID-19 pandemic has been a global disaster that has affected the lives of adolescents and their families on multiple levels. While physical health is understandably the priority during a pandemic, the impact of the COVID-19 pandemic and resulting measures on mental health has also been a major concern [1]. Indeed, the scientific literature provides clear evidence of the psychological and psychiatric impact that general health conditions have had on the general population [2,3].

Since the beginning of the COVID-19 epidemic, researchers around the world have focused more on the impact on mental health in the children and adult population, while, in our opinion, little attention has been paid to the effects of COVID-19 on adolescent mental health.

Adolescence usually includes people aged between 10 and 19 years [4], while people from 19 to 25 years old are considered young adulthood [5].

Adolescence has often been labeled by developmental theorists as a time of storm and stress [6] both due to physical and chemical changes [7] and the regulatory system still largely underdeveloped until early adulthood [8]. Another distinctive feature of adolescence is the marked increase in social sensitivity and the importance of peers [9]. These essential characteristics of adolescence have been severely threatened by the pandemic. Indeed, Gruber et al. [1] conceptualized the COVID-19 pandemic as a multidimensional stressor [1].

Furthermore, adolescence is a developmental stage in which many psychological symptoms increase in prevalence and numerous psychological problems may emerge for the first time [10].

On the other hand, adolescence, with its ongoing changes in behavioral functions and underlying neural circuits represents a "window of opportunity" to carry out early interventions in the prevention of the development of psychopathologies [11].

It is important to highlight that possible psychopathological alterations are not equally likely in all adolescents. Disasters tend to amplify pre-existing social (education, income, access to healthcare, access to other support services including psychological support) and personal (aspects relating to resilience) inequalities, resulting in an unequal impact on young people [12,13].

If we take into consideration that approximately a quarter of the world's population is represented by adolescents [14] and that about 75% of mental disorders begin before the age of 25 [15], the mental health of adolescents becomes an aspect of primary global importance.

Moreover, developing a serious mental disorder at a crucial time in life is an important predictor of persistent negative socioeconomic and health outcomes, such as economic disengagement, unemployment, low income, welfare dependency, low education and illness [16-18].

However, available evidence suggests that relatively mild mental disorders that develop during adolescence often do not persist into early adulthood [19]. Therefore, youth-focused interventions designed to reduce the risk of symptom onset or prevent progression from relatively mild mental health problems to more serious mental health problems can have a significant impact on long-term economic, educational and health outcomes.

Although past literature reported a growing trend of psychopathological aspects in adolescents before 2019 [20,21], according to the global estimate, in the year 2020 between 10-20% of adolescents would have suffered from mental health problems [22]. Numerous studies have established an association between the COVID-19 pandemic and rates of anxiety [23-27]. Other research has identified a high association between the pandemic and depression [28-31]. The study conducted by Duan et al. [24] identified an association between depression and social media use, such as smartphone addiction and Internet addiction. Guo et al. [32] identified an association between COVID-19-related stress and depression.

Surveys of young people's use of psychoactive substances report an initial decrease in alcohol and drug use, perhaps partly due to fewer opportunities for social use [33]. Other studies suggest that frequent and problematic substance use during the pandemic has increased in some high-risk youth, such as those with comorbid psychopathology [34-37].

Studies on suicide risk and/or attempted suicide have reported no increased rates of death by suicide [38,39]. Regarding emergency room visits for suicide attempts, the data are conflicting. One study reported a decrease in hospital attendance for self-harm behavior in the early months of the pandemic [40], while others reported small increases in suicidal ideation and suicide attempts among young people presenting to children's hospitals [41] and those admitted for a psychiatric condition [42].

During the COVID-19 pandemic, adolescents with a previous diagnosis of anorexia nervosa reported a 70% increase in poor eating habits and an increase in thoughts associated with eating disorders [43]. Furthermore, an unprecedented increase in the number of hospitalizations for restrictive eating disorders has been reported [44,45].

Pre-pandemic maltreated adolescents experienced higher rates of post-traumatic stress disorder (PTSD) and higher rates of anxiety [31]. The study [46] which evaluated various groups of young people, including adolescents diagnosed with OCD, established a worsening of symptoms (44.6%). Adolescents suffering from conduct disorders and Attention-deficit/hyperactivity disorder (ADHD) presented an increase in externalizing symptoms [47]. Furthermore, observed increases in externalizing symptoms were highly associated with lower levels of socialization and parental and peer support [48].

Regarding gender, studies have established higher rates of COVID-19-related anxiety among women [29,49].

Few studies have been conducted on marginalized groups [50] and adolescents with neurodevelopmental disorders such as autism, intellectual disability and ADHD [51].

For the mental well-being of adolescents, it appears important to also consider the effects that the restrictive measures linked to the pandemic have had on young people's family relationships. Some studies highlight the worsening of intra-family conflicts between parents and adolescent children in different ways at different times of the lockdown [52,53]. Other evidence suggests that spending more time with family during the pandemic was a protective factor for young people's mental health while spending more time online and more time connected virtually with friends were positively associated with depression [28].

The effect of the pandemic and the resulting restrictive measures on the use of social media by young people is important but still unclear. Although pre-pandemic literature has established a link between adolescents' excessive use of social media and poorer psychological well-being, such as depressive symptoms [54], risky behaviors [55], and body image disturbances [56], studies carried out during the pandemic led to ambiguous results [57].

Furthermore, recent reviews classified risk and protective factors for the mental health effects of the COVID-19 pandemic [58-60].

The main aim of this paper is to critically review the unmet needs necessary for developing integrated mental health services for adolescents and young people and to provide recommendations to be implemented in mental health services.

Materials and Methods

A literature search was conducted on major databases to find useful studies for the purposes of this paper.

Discussion

The effects of the COVID-19 pandemic on adolescent well-being have reinforced the importance of putting systems in place to support adolescent well-being. The Partnership for Maternal, Newborn & Child Health, and the World Health Organization (WHO) in collaboration with the United Nations H6+Technical Working Group on Adolescent Health define children and youth well-being as “having the support, confidence, and resources to thrive in contexts of secure and healthy relationships, realizing their full potential and rights” [61]. In 2020, Ross et al. [62] proposed five interconnected well-being domains with subdomains and requirements (e.g., good health and optimum nutrition, learning and competence, connectedness, safety and supportive environment, agency and resilience).

In 2002, the WHO identified five key points to promote the delivery of quality health care for young people consisting of accessibility, acceptability, appropriateness, effectiveness, and equity of care [63]. Moreover, six different groups of youth-friendly health services have been delineated:

a) health service specialized in children and adolescent care in a hospital setting;

b) similar specialized service located in the community;

c) school or college-based and stakeholders connected with schools or universities;

d) community-based center providing health services and other services (e.g., help with literacy and numeracy skills);

e) pharmacies and shops that sell health products but do not provide health services;

f) outreach information and service provision.

O’Brien et al. [64] reported the gap between the prevalence of mental disorders in young people and the rates of access to treatments (25-35%), highlighting an important paradox: people with the highest level of need have the worst chance of treatment.

Many factors must be taken into consideration regarding the difficulties and barriers that young people encounter in accessing mental health services, which in our opinion, can be summarized in three factors: service, personal and social factors.

The discussion of barriers related to service factors should start from the original bifurcation of pediatric services and adult services, still leaving a gap for services for adolescents [65]. Primary care professionals experience difficulties in the recognition of youth mental health problems [64] and have already expressed a need for better training in adolescent health [66,67]. Furthermore, poorly trained health professionals encounter difficulties in communicating with young people and their parents [68]. Young people often are unhappy with the consultation resulting in high dropout rates [69]. There are difficulties in receiving the first visit [70] and delays in starting treatment [71]. Some services are inaccessible for reasons relating to cost, where they are located, limited opening hours or lack of advertising and visibility [72-74].

A recent systematic review [75] showed young people's stigmatizing beliefs about mental healthcare, mental health professionals, and access to care. Many adolescents report fear of a lack of confidentiality from health workers [76], about being recognized in a clinic waiting room and about being scolded or carrying out unpleasant procedures [77].

Social determinants frameworks appear to be related to many health inequalities and differential access to resources around the world, such as economic stability, education access and quality, healthcare access and quality, neighborhood and built environment, and social and community context [78]. Extensive evidence supports the impact of social determinants on mental health [79,80]. In some developing countries, restrictive laws and policies limit access to services for some groups of young people [81]. Moreover, during the pandemic, marginalized groups have been less able to engage with telehealth ser-vices [82].

Currently, mental health services are still predominantly organized around diagnostic categories diagnoses of adult mental disorders [83] that are poorly adapted to the developmental characteristics of adolescents. Indeed, the current diagnostic systems for mental disorders (DSM-5 and ICD-11) do not allow a diagnosis to be made if symptom expression is below a certain cut-off value.

Over the years, alternative approaches that reflect psychopathological dimensions have been advocated such as the Research Domain Criteria [84] and the Hierarchical Taxonomy of Psychopathology (HiTOP) [85], but proposals for an evolutionary perspective on emerging psychopathology have been rare [85,86].

Dimensional approaches are certainly necessary for the clinical evaluation of sub-threshold or prodromal symptoms that allow early interventions and preventions to be carried out.

The cornerstone of early intervention in psychiatry was certainly represented by early intervention for psychotic disorders [87] based on the clinical stage model of mental disorders [88]. Subsequently, similar interventions have been proposed for bipolar dis-orders [89] and major depressive disorders [90].

On the other hand, according to Rose’s Strategy for Preventive Medicine [91] “a large number of people exposed to a small risk may generate many more cases than a small number exposed to a high risk”. From this perspective "the high-risk strategy" could be less effective in reducing the prevalence of the disease than "the population strategy".

Public health is a term “coined in the early 19th century to distinguish actions governments and societies - as opposed to private individuals - should take to preserve and protect the people’s health” [92]. Therefore, if we wanted to intervene in public mental health, we should dedicate more resources to prevention rather than treating the individual through “the population strategy”.

Regarding adolescents, “the population strategy” translates into interventions aimed at the multiple factors that can influence the mental health of young people.

Recently, Fazel and Soneson [93] have proposed a new conceptual framework of interventions entitled “the Interactional Schema” of child and adolescent public mental health. This schema places an enhanced emphasis on the interactional nature of three factors influencing child and adolescent mental health: interpersonal, community and institutional. The framework de-emphasizes individual-focused interventions by encouraging public health and prevention approaches especially with interventions de-livered outside specialist mental health settings.

To address the shortcomings of the health system for the mental health of young people, since the beginning of this century, broad-spectrum approaches have emerged [94,95] with models of integrated primary mental health care [96].

Literature provides multiple definitions of integrated healthcare [97], but the one that best suits the purposes of this article is “…changes to health or both health and health-related service delivery which aim to increase integration or coordination” [98].

Starting from the project called “Headspace” founded in Australia [99], we are witnessing a global renewal in youth mental healthcare characterized by multidisciplinary, integration and delivery in a single setting that constitutes a soft entry point to mental healthcare. Numerous nations all around the world are now adopting an integrated youth primary care model [100].

Common features of these models include:

a) clear separation of services for young people from those of children and adults with particular attention to the transition phase;

b) greater participation of young people in service planning and reduction of stigma;

c) single healthcare location with high visibility in the local community;

d) flexible and soft approach to diagnosis especially in the early stages of mental ill-health.

A growing literature is highlighting the improvement in the possibility of accessing services, short-term clinical improvements and high levels of satisfaction among families [101-103].

Due to the negative outcomes of the COVID-19 pandemic on mental health among adolescents, it is imperative to provide strategies to prevent the onset of even serious psychopathological alterations today and in the future [104].

The COVID-19 pandemic has certainly represented a global disaster, but it may also have created countless possibilities for changes in youth mental health services and interventions. In this sense, the restrictive measures adopted to stem the COVID-19 pandemic could represent an issue to reflect on for future public health interventions.

In our opinion, the revolution of the youth care system should include two fundamental macro-areas integrated with each other: re-think public health institutions and promote prevention/early interventions.

Public health institutions include national and international organizations (e.g., the WHO), Ministry of Health, governments, local administrations, national health systems (where present), mental health services, primary, secondary, tertiary care, schools, etc.

Greater cooperation and integration between institutions appear necessary, to reduce the marginalization of minority groups, promote equality of rights and social security policy, address poverty and socioeconomic inequality and greater equity in the possibility of access to care. So far, the effects of these policies on mental health appear mixed [105-107].

An important aspect of the implementation of the care system is represented by the incorporation of the point of view of adolescents. Co-production experiences have shown positive results [108,109].

For about fifteen years, the WHO has recognized primary care as the heart of mental health care [110] as numerous advantages are using this approach (i.e. reduced stigma and barriers, feasibility across most healthcare contexts, etc.). Previous reviews have reported positive data on primary [111,112], secondary and tertiary integration interventions [113] in terms of better accessibility to health services, reduction of waiting times and better early detection of health problems and treatment. Furthermore, health services should have a more widespread presence throughout the territory, particularly primary care, even in the most rural areas, with the possibility of carrying out home interventions.

To reduce barriers, improve the engagement of young people and make the first contact with institutions more accessible, there are some experiences with voluntary youth or paid peer workers [114,115].

The integration of new digital technologies could on the one hand improve accessibility and engagement to care and on the other be used to carry out therapeutic interventions [116-119]. This has been especially true during the COVID-19 pandemic [120]. Digital technologies can also be used in population-based prevention approaches and to help prevent relapse [121,122].

As regards health specialists, and in particular mental health, more training should be carried out for the recognition of the first stages of psychopathological alterations, but also to improve the relationship with young people. A new model of youth mental health care should be fostered with the establishment of a new subspecialty of youth psychiatry, separated from the medical model of pediatrics and in close collaboration with adult psychiatry.

The literal meaning of the term “prevention” is “the act of preventing something from happening” [123]. Based on the moment in which it acted during the pathology, the prevention phases were classified as primary, secondary and tertiary [124]. For the purposes of this article, we will not take into consideration the phases of the disease to be prevented, but the areas in which to act and in particular: the family and peers, the community, the school and the individual.

Family and peer relationships play a key role in youth well-being [125-127]. Scientific literature supports strong evidence on the health of young people with parenting interventions [128]. Moreover, treatment of parental mental illness can reduce the risk of new diagnoses in children [129]. Friendship interventions reported limited evidence on adolescents’ mental health [130].

Social and independent activities in the natural environment can improve mental health outcomes, but there is little evidence that these interventions may have on the incidence of new psychopathological disorders [131-133]. Social cohesion may help protect against the development of anxiety and depression among adolescents and young adults [134]. Important opportunities for intervention in the community are represented by participation in artistic and recreational activities [131,135,136].

Awareness, anti-stigma and mental health promotion campaigns are of fundamental importance for raising awareness among the general population, but most are generic or for adults [137].

The school, even if it is considered an institution, represents a focal point of prevention interventions as a place of relationships between individuals, peers, families and communities. It also represents a fundamental place in the recognition of non-clinically significant symptoms, where preventive interventions can be carried out constantly and systematically. Numerous prevention interventions have been carried out within schools for suicide, self-harming behaviors, substance misuse and bullying with variable efficacy data on young people's well-being [138-142]. Furthermore, good evidence supports the positive effects of physical activity during school hours on students’ mental health [143,144].

For interventions on the individual, the first step to take is to focus on new diagnostic approaches, facilitating interventions for subthreshold expressions of emerging psychopathology as early as possible. As already demonstrated, younger age of onset is a predictor of longer duration of symptoms, comorbidities and worse outcomes [145].

Even if the literature highlights the greater effectiveness of indicated prevention interventions [146,147], in our opinion, we should first focus more on universal and selective prevention interventions through primary care and school and only subsequently, on indicated interventions provided by secondary care systems and tertiary.

In summary (Figure 1), the key recommendations for implementing public health institutions include:

a) Greater cooperation and integration;

b) Co-production experiences with adolescents;

c) Implementation of primary care;

d) Integration of voluntary youth or paid peer workers;

e) Integration of new digital technologies;

f) Better training and subspecialty.

On the other hand, the key recommendations for prevention include:

a) Parenting and peer interventions;

b) Social activities;

c) Mental health promotion campaigns;

d) School interventions;

e) Dimensional approach;

f) Primarily a universal intervention.

Lastly, we completely agree with Fazel and Soneson's statement “…mental health interventions are not necessarily confined to an individual psychological and/or pharmacological approach, and many children and adolescents could stand to benefit from interventions that take a broader view of the multitude of interpersonal-, community- and institutional-level factors that influence mental health”.

Conclusion

Due to dramatic and sudden changes in their lives during the pandemic, thousands of teenagers around the world could still be at risk for psychopathological disorders creating a mental health “pandemic” scenario.

We believe they deserve an inclusive response in terms of global health measures to avert potentially serious and long-lasting effects in terms of marginalization, stigma and psychopathological developments. Vertical, horizontal and longitudinal integration should be promoted. Despite scientific evidence, the institutions that deal with the mental health of young people are still inefficient even with new approaches that are still not widespread in the world.

The current lack of an adequate care system requires an absolute priority in carrying out a conceptual and practical revolution of health services for the current and future well-being of young people. On the other hand, broader prevention campaigns should be implemented to intercept potentially serious dimensional clinical aspects from a longitudinal perspective.

Thinking of the mental health of young people as a common good to be protected, the fundamental changes to be made are in the internal world and the external world of the individual, of the community, of public health institutions.

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Wednesday, July 15, 2026

Effects of Manual Lymphatic Drainage Combined with Press-Release Method Orthopedic Manual Lymphatic Physiotherapy on Upper Extremity Edema and Shoulder Joint Range of Motion and Pain in Patients with Breast Cancer- Juniper Publishers

 

Journal of Surgery- Juniper Publishers

Abstract

Purpose: The purpose of this study is to investigate the effectiveness of orthopedic manual lymphatic drainage techniques to move fluid and soften hardened tissues using functional assessment of the upper extremity of patients after breast cancer surgery, as well as edema and pain scales.

Methods: The study included 24 patients diagnosed with lymphedema following mastectomy surgery, who received the intervention twice a day, three times a week for six weeks, and were evaluated for upper extremity swelling volume assessment and shoulder joint range of motion and pain sensory.

Results: In conclusion, this study demonstrates that the integrated lymphatic therapy approach of orthopedic manual lymphatic physiotherapy is an effective treatment for reducing edema, improving shoulder joint range of motion, and reducing pain sensory in the upper extremity in postoperative patients with breast cancer.

Conclusion: Orthopedic manual lymphatic physiotherapy with press-release techniques was effective in improving upper extremity edema, shoulder joint range of motion, and pain in a post-breast cancer surgery patient.

Keywords: Edema; Manual Lymph Drainage; Orthopedic manual lymphatic physiotherapy; Interstitial fluid; Alpha waves

Abbreviations: CDT: Complete Decongestive Therapy; DASH: Disabilities of the Arm, Shoulder, and Hand; NRS: Numeric Rating Scale; MLD: Manual Lymphatic Drainage; MWF: Mobilization with Facilitation; KPIMT: Korea Pediatric Integrative Manual Therapy; SF-MPQ: Short-Form McGill Pain Questionnaire

Introduction

In recent years, breast cancer is ranked second in the five-year cancer prevalence rate among women in Korea with 21.9% per 100,000 population, and the incidence of breast cancer has also increased rapidly, ranking first among newly diagnosed malignant neoplasms in women with 20.3%, and by age group, it is ranked first in the 35-64 age group with 29.1%, and the five-year survival rate is 96.8%, showing a high survival rate [1].

Lymphedema, which occurs after cancer progression and treatment, was found to occur in more than 50% of breast cancer patients [2], who underwent surgery to remove the lymph nodes in the armpit and radiation therapy, and in more than 64% of patients who underwent surgery to remove the lymph nodes in the groin or pelvis [3]. Lymphedema is a soft tissue swelling caused by the accumulation of proteinaceous fluid in the pericellular space of cells. This reduces the carrying capacity of the lymph and increases the lymphatic load. The severity of lymphedema is graded using the International Society of Lymphology’s scale [4]. Lymphedema is a chronic, progressive condition in which the swollen area increases in size and weight, limiting motion and joint movement with postural changes and pain in daily activities. Conservative treatment with radiation therapy is associated with decreased shoulder joint range of motion, localized dysfunction, and the development of lymphedema [5].

In addition, lymphedema occurs in about 20 to 40 percent of patients after surgery, such as mastectomy and lymph node dissection, and is associated with upper arm dysfunction, including numbness, pain, limited range of motion in the shoulder joint and neck, tendonitis of the rotator cuff, and decreased muscle strength [6,7]. In recent years, some researchers have been working on controlled studies to determine the effectiveness of orthopedic manual physical therapy with Manyal Lymph Drainage (MLD), but the results are still controversial. Multiple Continuous compression is accepted as an essential part of treatment [8]. This effect has been shown to reduce edema by 7-17 % when compression methods such as compression stockings are applied without any other treatment [9].

MLD improves the appearance of edema by improving microvascular tone and increasing mobility, but because MLD is usually performed in conjunction with compression, it is difficult to conclude that it is effective in reducing edema by more than 60%. It would be unreasonable to attribute this effect to MLD alone, The Other Study demonstrated a 20% reduction in edema with a low-elastic bandage and orthopedic manual physical therapy with MLD, while Johansson et al. validated the effectiveness of orthopedic manual physical therapy with MLD alone with a statistically significant difference of more than 7% in favor of MLD over bandage alone [10,11].

Therefore, this study aimed to investigate the effects of applying orthopedic manual physical therapy with MDL technique using upper extremity orthopedic manual physical therapy using mobilization with Facilitation technique and Press - Release technique, a new physiotherapy treatment method, on changes in upper extremity swelling circumference, shoulder joint range of motion assessment, and pain sensation in breast cancer patients, and to provide a basis for future research on physiotherapy intervention programs.

Methods

Participation

In this study, 24 patients who were diagnosed with lymphedema after mastectomy surgery at J Hospital Cancer Specialized Rehabilitation Center located in Jeollanam-do were included in the study from the beginning of June 2023 to the end of March 2024, and the circumference of the swelling area and the contralateral upper limb differed by more than 2 cm, the skin condition of the upper limb was not problematic for applying the bandage method, and the patient was able to perform upper limb exercises according to the therapist’s instructions.

Inclusion criteria for the study were:

 Diagnosed with unilateral lymphedema.

 No active cancer.

 No joint movement restrictions.

 Not taking any medications, foods, etc. that may affect the reduction of edema, such as diuretics that may affect edema reduction.

 No neurological conditions that could affect measurements.

 Guardian has agreed to participate in the study.

Before participating in this study, all subjects were fully informed of the purpose, content, and methods of the study, and only those who voluntarily signed an informed consent form were included in the study. Patients with any of the following conditions were excluded from the study.

 Individuals with cardiac dysfunction and acute thrombosis.

 Individuals with dermatitis.

 Those with acute malignant lymphedema.

 Subjects with arm paralysis and vascular disorders.

 Participation in a study like this study within the last 1 year.

Measures and Procedure

This case study was conducted after obtaining informed consent in accordance with the Declaration of Helsinki. The procedure of this study is as follows (Figure 1). The G-Power 3.0 program (IBM Inc., USA) was used to determine the sample size of this study. To calculate the sample size, the significance level (α) was selected as 0.05, the power (1-β=0.8) was selected as 0.48, and the effect size (d) was calculated using the preliminary experiment.

A minimum of 12 subjects were required for each group, for a total of 24 subjects. The subjects were randomly assigned to the MLD group and the control group. The subjects were randomly assigned and grouped using randomization software (Random allocation software version 1.0, University of Medical Sciences, USA). In this study, the intervention was delivered three times a week, twice a day for six weeks, for a total of 36 sessions. The pretest included general characteristics, upper extremity edema assessment, shoulder joint range of motion, and pain sensation (Figure 2).


Assessment of Edema of the Upper Extremities

When Assessment upper extremity (Figure 2) edema, upper extremity circumference was measured 10 cm below the patient’s elbow joint with a measuring tape (Arm Circumference Gauge, Sammons Preston, USA), a method proven reliable in Taylor’s experiment [12].

Assessment of Range of Motion of Shoulder Joint

To observe the range of motion of the upper extremity before and after treatment, the shoulder joint range of motion was tested using a goniometer. Active flexion, abduction, and external rotation of the shoulder joint were measured in the edema position. The flexion of the shoulder joint was measured while lying supine, bending the knees and hip joints, and placing the feet flat on the floor to prevent hyperextension of the lumbar spine. The elbow joint was extended, and the forearm and palm were kept supinated. The axis of the joint goniometer was aligned with the acromion process of the scapula, which passes through the humeral head. The fixed arm was positioned at the mid-axillary line of the torso, and the movable arm was measured after being positioned at the outer midline of the humerus.


Shoulder joint abduction was measured in the supine position with knees and hips bent and feet flat on the floor. The arm being measured was placed in an anatomical position, and the elbow joint was maintained in an extended state. The axis of the joint goniometer was aligned with the anterior part of the acromion process of the scapula through the center of the humeral head. The fixed arm was parallel to the midline of the sternum and placed on the lateral surface of the anterior surface of the ribcage, and the movable arm was parallel to the midline of the humerus and placed on the anterior surface of the arm before measurement. External rotation of the shoulder joint was measured in the supine position with the knees and hip joints flexion and the feet flat on the floor.

The axis of the joint goniometer was aligned so that the direction of the humeral head coincided with the olecranon process of the ulna passing through the humeral body. The fixed arm was positioned perpendicular to the floor, and the movable arm was measured after being positioned on the ulnar body in the direction of the styloid process of the ulna [13].

Assessment of Pain sensory

The short-form McGill pain questionnaire (SF-MPQ) was used to measure pain sensory, and the reliability of the measurement tool was r=.89.14 The SF-MPQ consists of a total of 15 questions, including 11 questions in the sensory domain and 4 questions in the emotional domain, and can evaluate the sensory and emotional components of pain [14,15]. Each item is rated on a 4-point Likerd scale from 0 (no pain), 1 (mild pain), 2 (moderate pain), and 3 (severe pain). The higher the summed score, the higher the pain sensation. A physical therapist explained to the subjects how to fill out the questionnaire, and self-assessed the questionnaire while the subjects were stable.

Intervention

Experimental Group

The intervention for the MLD technique of the Press-Release technique was administered twice a day, three times a week for six weeks, and was applied for 20 minutes each. The subject was asked to lie down on the treatment table, place a pillow under the knees, bend the hip joint at 70°, and relax the muscles as much as possible. Korea Pediatric Integrative Manual Therapy (KPIMT) Press Release Therapy and Mobilization with Facilitation therapy [16,17]. KPIMT muscular skeletal factor kalten born segmental movement and mulligan concept where there is an arbitrary restriction of movement of the incorrect musculoskeletal system [18,19].

The coordinative control of the use of the arms and hands mixed with the spine, through the handling input of the therapist, with the distribution of various contacts, sufficient proprioceptive and somatosensory input, and through the guiding and assisting of the hand, the sensor light is sufficiently turned on. Mobilization with Facilitation (MWF) technique and stretching release technique and press release technique are applied to each joint junction for inputting somatosensory and proprioceptive sensory information of the muscle when providing sufficient support for the ability to recover balance from touch to come.16 Provides joint stability and Recovers pain by stimulating the parasympathetic nerve and increasing lymph vessel flow [16].

PR technique treatment area and pressure stage; The pressure level of the treatment is divided into skin surface, dermis layer, fascia surface, and submuscular area according to the depth, and the level of force is divided into 1-4 levels, changing depending on the treatment area.

Before all lymphatic physical therapy, pump Jugular angle area 25 times before performing the next treatment [16].

This section deals with the axillary group and hand arm region. the muscle each group muscles (apex, base, medial lateral posterior, anterior). ① Effleuage→ ② Treatment of the Apex part of infraclavicle lymph nodes → delto-pecto lymph nodes → axillary lymph nodes and trapeziurs and deltoid muscle (pressrelease technique 20 ) → ③ Treatment of the Base part of Latissimus dorsi and teres major (press-release technique 15) → ④ Treatment of the Medial Border part of serratus anterior and inter costalis muscle (press-release technique 15) → ⑤ Treatment of the lateral border part of Coracobrachialis and bicepce muscle (press-release technique 15) → ⑥ Treatment of the Anterior wall of Pecto major and minor and subclavicles muscle with anterior wall Cord bending technique (press-release technique 15) → ⑦ Treatment of the posterior wall of Latissimus dorsi and teres minor muscle (press-release technique 15) → ⑧ External Rotation Techniques to increase scapulo-humeral joint range of motion → ⑨ Posterior wall Cord bending technique → Pump stroke stage of Upper arm (Deltoid → Biceps → Triceps 15section) and Lower arm (Supnation and Pronation Scoope stroke) → Hand Pump ans thumb circle strock→ Ocillization ⑩ Effleuage (Figure 3).

In the afternoon section treatment, the upper limb bandaging method was performed for 20 minutes followed by a 10-minute rest. The bandaging method applied to the patient’s upper limb was to fold a 4 cm bandage in half, wrap it loosely around the finger, and then apply a cotton stockinette to the upper limb. I wound it on. Afterwards, an undercast pad was added to the wrapped from the fingers upward to the upper limb [20]. For the compression bandage, Lohmman and Rauscher’s low elastic bandage (Germany) was used in both the experimental and control groups.

Control Group

The control group intervention was performed three times a day, every other day for six weeks, with subjects in the supine position on the treatment table, as relaxed as possible, receiving 20 minutes of multi-chamber pneumatic compression per intervention, followed by 10 minutes of relaxation for 10 minutes. The pressure was kept below 30mmHg to prevent further damage to the lymphatic system in the upper extremity. In the afternoon section, the treatment consisted of 20 minutes of upper extremity bandaging followed by 10 minutes of rest. In the afternoon section, bandaging was performed in the same way as in the experimental group.

Statistical Analysis

The data collected in this study were subjected to statistical analysis using SPSS for windows (version 21.0). Descriptive statistical methods were used to determine the subject’s age, weight, height, medical treatment, and area of edema, and an independent samples t-test was performed to determine the homogeneity of the experimental and control groups. For the differences in arm circumference, shoulder joint range of motion, and pain sensation for comparison of edema volume before and after treatment between the experimental and control groups, a Wilcoxon rank test was performed to test the significance before and after treatment of each group, and the differences between each group were performed. To find out, the Mann-Whitney U test was performed. The significance level was set at 0.05.

Results

The total number of subjects in the study was 24 women, and the medical characteristics of the subjects in the study were as follows: 12 (45%) of the 24 subjects received combined radiotherapy and chemotherapy, 9 (40%) received chemotherapy, and 3 (15%) received radiotherapy. An independent samples t-test was performed to test the homogeneity of the experimental and control groups. The location of the edema in the study included 16 (75%) left upper extremity, 8 (35%) right upper extremity, and 24 (100%) had edema in both proximal and distal parts of the upper extremity (Table 1).

Pre-post Treatment Upper Extremity Volume Changes to Assess Edema in Experimental and Control Groups: The volume of the upper arm and forearm of the experimental group decreased significantly from pre-treatment to post-treatment. In the control group, the decrease was significant for the upper arm but not for the forearm (Table 2) (p<0.05).

Compare the Range of Motion of the Shoulder Joint: Changes in pre-post treatment range of motion of the shoulder joint between the experimental and control groups There were statistically significant differences in the pre-post treatment range of motion of the shoulder joint between the experimental and control groups for flexion, abduction, and external rotation, and only for abduction in the control group (p<0.05) (Table 3).






Comparison of Pain Sensory: The changes in pain sensation of the experimental group and control group according to the intervention are as follows (Table 4). The pain sensation before and after the intervention for each group was compared by paired sample t-test, and there was a statistically significant difference after the intervention in the experimental group (p<.05) (Table 4).

Discussion

This study aims to explore a manual lymphatic drainage (MLD) therapy program that incorporates upper extremity orthopedic lymphatic physiotherapy, which is more effective than compression methods used in physical therapies for the therapeutic management of upper extremity lymphedema following mastectomy.

Specifically, this study evaluates effects on edema, range of motion, and pain sensation in the upper extremities of patients with lymph edema. The overall mean age of the participants was 52.25±8.96 years; this is slightly higher than the findings of the Korea Central Cancer Registry, reporting the highest incidence of breast cancer in women aged 40-49 years in Korea.

However, this could be attributed to the random selection of patients within a specific period and the overall incidence rate is expected to align with the Registry’s findings [21]. Tumor locations were 55.0% left-sided and 45.0% right-sided, aligning closely with the findings reported by the Korean Breast Cancer Society, with 51.6% left-sided, 47.5% right-sided, and 0.9% bilateral [22]. Lee and Bae [23] also reported a similar pattern, with a higher number of patients with left-sided breast cancer than those with right-sided [23]. According to the American Cancer Society, one in eight American women is expected to develop breast cancer, with incidence rates being exceptionally high among women aged 50-59 years, like the findings of the Korea Central Cancer Registry [24].

In addition, Siotos [25] found the upper outer quadrant of the breast at a 36.2% incidence as the most common tumor location, followed by the upper inner quadrant at 13.1%, the lower outer quadrant at 9.8%, the lower inner quadrant at 7.2%, the nipple at 1.2%, the axillary tail at 0.3%, and overlapping regions at 24.7% [25]. Post-surgical treatment among the 24 participants included radiation and chemotherapy in 45%, chemotherapy alone in 40%, and radiotherapy alone in 15%, with radiation identified as a significant risk factor for lymphedema [26]. However, this study selected patients exhibiting lymphedema on both the proximal and distal sides of the upper extremity that differed by more than 2 cm from the normal side, irrespective of their medical treatment type, limiting the correlation between treatment method and lymphedema occurrence in the participants.

The results of this study showed a significant decrease in pain sensation after intervention (p<.05). The lymphatic system plays a crucial role in maintaining homeostasis of macromolecules, lipid absorption, immune function, and interstitial fluid regulation. Its main feature is the ability to remove interstitial fluid and proteins from the interstitial space, draining them from the interstitial space into the vasculature [27]. In their study on the use of physiotherapy and exercise therapy after mastectomy in women aged 65 years and older, Tunay et al [28], found significant reductions in pain and improvements in shoulder function, range of motion during flexion, abduction, and external rotation, muscle strength, physical function, and quality of life, as well as a decrease in lymphedema volume [28]. In another study, Cho et al [29], compared conventional physical therapy with manual lymphatic drainage applied three times a week for four weeks in 41 patients with lymphedema and a pain scale score of 3 or higher [29]. They found significant improvements in functional and symptomatic aspects, shoulder flexor muscle strength assessed by the DASH (disabilities of the arm, shoulder, and hand) score, and pain levels measured by the NRS (numeric rating scale). Moreover, they noted a more significant difference in the group receiving combined conventional physical therapy and manual lymph drainage compared to those receiving conventional physical therapy alone, which is consistent with the results of this study.

MLD techniques enhance the movement of lymphatic fluid in the interstitial space, contributing to the removal of interstitial fluid. This drainage into the venous system improves venous return, reduces systemic vascular resistance, and facilitates oxygen delivery to cells. In other words, the improved blood circulation after the intervention is believed to facilitate the muscle cell oxygenation, consequently alleviating pressure on the muscles and, thus, contributing to the reduction in muscle tone [30]. Continuous light stimulation during moderate pressure massage activates Aβ fibers, stimulating the substantia gelatinosa in the spinal dorsal horn and inhibiting pain transmission [31]. Additionally, oxytocin’s activation of the endogenous pain control system induces analgesic effects [32,33]. This study suggests that the press-release rhythmic stimulation effectively reduced pain in patients with breast cancer.

Research suggested post-surgical exercises for patients with breast cancer to reduce complications and improve physical function, including flexibility exercises to smooth joint range of motion, muscle strength exercises, and exercises to strengthen cardiorespiratory function and increase stamina. [34] A similar study compared the effectiveness of MLD and complete decongestive therapy (CDT); this physical therapy regimen includes compression bandaging in moving fluid and reducing limb volume in 13 patients with lymphedema of the lower extremities. The study found that the volume of the leg and the amount of intracellular and extracellular fluid decreased when using the physical therapy regimen compared to CDT [35]. Orthopedic manual lymphatic physiotherapy integrated with MLD influences the body through various mechanisms. It has been reported to reduce excessive sympathetic nervous system activity due to stress or other factors and enhance parasympathetic nervous activity, promoting relaxation. Additionally, it increases the activity of alpha waves, associated with relaxation and calmness, and decreases gamma waves, activated during extreme arousal and excitement [36]. This study suggests that the press-release rhythmic stimulation used in orthopedic manual lymphatic physiotherapy, akin to functional massage, facilitates muscle relaxation and joint mobility as well as optimally applies lymphatic treatment. This approach improved the range of motion and reduced pain in the shoulder joint, as evidenced by the study’s results.

However, this study has certain limitations stemming from the number of local participants and the control of external variables. Future research should involve a larger sample size and more controlled measurement of various variables.

Conclusion

This study investigated the effectiveness of orthopedic manual lymphatic physical therapy using the press-release technique in improving upper extremity swelling, shoulder joint range of motion, and pain in patients after breast cancer surgery.

 The volume of the upper arm and forearm of the experimental group decreased significantly from pre-treatment to post-treatment. In the control group, the decrease was significant for the upper arm but not for the forearm (p<0.05).

 Changes in pre-post treatment range of motion of the shoulder joint between the experimental and control groups There were statistically significant differences in the pre-post treatment range of motion of the shoulder joint between the experimental and control groups for flexion, abduction, and external rotation, and only for abduction in the control group (p<0.05).

 The changes in pain sensation of the experimental group and control group according to the intervention are as follows (Table 4). The pain sensation before and after the intervention for each group was compared by paired sample t-test, and there was a statistically significant difference after the intervention in the experimental group (p<.05).

Orthopedic manual lymphatic physiotherapy with pressrelease techniques in manual lymph drainage was effective in improving upper extremity edema, shoulder joint range of motion, and pain in a post-breast cancer surgery patient.

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