Showing posts with label Hypertension. Show all posts
Showing posts with label Hypertension. Show all posts

Monday, October 16, 2023

Stress Among College Students is Linked to Headache, PCOS, Hypertension, and Depression: A Cross-Sectional Study - Juniper Publishers

 Psychology and Behavioral Science - Juniper Publishers


Abstract

Objective: In the present study, we aimed to find out the prevalence of stress among college students.

Methods: In this descriptive cross-sectional study, a simple random sampling approach was chosen for data collection from different colleges of Jammu & Kashmir (UT). Data analysis was done by using the chi-square test, and the t-test was utilized for discrete and continuous variables respectively. The logistic regression model using odds ratio was utilized to find out the association between the risk variable and the dependent variable.

Results: A total of 1405 college students were included in which stress was found in 60.49% of students with males representing 34% and females 65.88%. Educational stress was found to be the major contributor of stress-type faced by the students with 46.35%. Different disorders were also observed in students including hypertension 2.70%, PCOS (Poly-cystic ovarian syndrome) 2.34%, and depression 2.84%. Stress was found associated with the PCOS with OR: 3.62 [95% CI: 1.4850-8.84, p-value: 0.0047], headache OR: 3.67, hypertension OR: 5.31 [95% CI: 2.06-13.70, p-value: 0.0006] and depression OR: 7.24 [95% CI: 2.56-20.48, p-value: 0.0002].

Conclusion: Educational stress is found to be very common among college students which may alter the prosperous life of students. Female students were seen to be more stressed than male students. Stress has a strong detrimental impact on students’ health because it is considerably linked to conditions including hypertension, PCOS, and depression. Therefore, the educational system must need a better strategy that will ensure a better education system.

Keywords: Stress; Educational stress; Hypertension; PCOS; College students

Abbreviations: PCOS: Poly-cystic ovarian syndrome; SAA): Salivary Amylase Activity; FGD: Functional Gastrointestinal Disorders; IBD: Inflammatory Bowel Disease; PU: Peptic Ulcer; UC: Ulcerative Colitis; CRH: Corticotrophin Releasing Hormone; ACTH: Adrenocorticotropic hormone; OR: Odds Ratio; OECD: Organization for Economic Co-operation and Development

Introduction

In today’s world, many shortcomings need to be eliminated and education is the one that is often seen as a solution to many social problems. Education is an important instrument that has the power to make a person interactive, self-reliant, social, and disciplined. Education broadens the scope of learning by facilitating knowledge absorption and dissemination among people in order to advance society [1]. Every individual is bombarded with a multitude of perceptual information in their day-to-day life activities. Apart from such advantageous features of education, the ability to process information is limited and varies from person to person. These cognitive characteristics have the potential to disrupt students’ lives periodically, which might result in circumstances that resemble stress and anxietylike condition. According to physiological definition, stress may be described as “any form of change that results in bodily, emotional, or psychological strain or pressure”.

It could result from a traumatic, disappointment, or uneasy encounter or sensation [2]. It is not that stress is bad, “Eustress” describes stress as a “positive, motivating, and enhances functioning feature which leads to the excellent performance” while “distress” refers to bad and overwhelming stress full condition which leads to tiredness, despair, and a variety of other illnesses and thus impairs functioning [3]. Albeit intense or transient pressure can be helpful but ongoing pressure, which goes and remains for a more extended period, is very unfavorable to the body and causes hypertension, weight gain, sadness, and even coronary diseases [4]. The effects of anxiety on students’ academic performance were detrimental [5] and besides anxiety, another emotionally uncomfortable disorder that could interfere with a student’s life is depression.

Stress affects students’ life in a variety of ways, including how they perform academically, socially, physically, and emotionally [6]. Exam stress, a lack of interest in attending lectures, full schedules &responsibilities, lack of sleep, an inability to understand the topic, and academic pressure (pressure to achieve high marks and concerns about receiving poor grades) are some examples of stresses faced by students [7]. The cognitive system becomes overburdened under stressful settings, reducing the student’s attention and ability to process the perceived information [8]. Biologically, stress can lead to long-term health complications, chronic illness, and psychiatric conditions such as migraine, PCOS (poly Cystic Ovarian Syndrome), depression, and suicide [9-11].

The Organization for Economic Co-operation and Development (OECD) recently conducted a survey that included 540,000 students aged 15-16 years old from 72 nations which showed that education and academic achievement are major sources of stress for students [5]. Therefore, in the present study, we aim to find out the stress frequency among college students of Jammu division. To our knowledge, this is the first study that included 10 district colleges from our region. The remainder of the paper is laid out as follows: methods utilized in this study are depicted in Section 2, section 3 includes the result of the study, section 4 represents the discussion and the conclusion of the study is present in section 5.

Method

In this present descriptive cross-sectional study, a random sampling approach was chosen for data collection from different colleges in the Jammu division of Jammu & Kashmir (UT). The sample collection was done in two phases i.e., Phase-I (Face-face interview) and Phase-II (E-based sampling).

Sample Collection

A targeted survey was taken in the colleges of the Jammu division to gather data from the different college students. The information was gathered using two different phases, including face-to-face interviews (Phase-I) conducted by an experienced interviewer/ trained interviewer and online sampling/ E-Sampling using a google form (Phase-II). The questionnaire/ Google form was disseminated through emails and social networking sites. The present study design was duly approved by Animal and Human Experimentation Ethical Committee (AHEEC), University of Jammu vide notification number EC: DRS/22/4969.

Filtering and Data Cleaning

A large data set was obtained using the E-based sampling approach, and the data was cleaned and filtered using a variety of exclusion criteria to decrease redundancy and bias. Exclusion criteria include “students that did not belong from the district of Jammu division”, “non-college students”, “who don’t permit for use of their data (incomplete consent)”, and also the exclusion of subject data “who gave the partial information”.

Data analysis and statistics

For the descriptive data analysis, mean with Standard deviation and frequency distribution were used for the continuous and discrete variables respectively. The chi-square test and the t-test were utilized for the discrete and continuous variables, respectively, in the inferential statistics. The logistic regression model utilizing the odds ratio (OR) was used to determine whether the risk variable and the dependent variable i.e., diseases were associated or not. Online free statistical tools/calculators such as MedCalc’s Odds ratio calculator for calculation of Odds ratio, t-test were calculated by graph-pad Home-GraphPad and for chi-square statistics Social Science Statistics (socscistatistics.com) were used to draw out the inference.

Result

A total of 1405 college students were included with a mean age of 19.64±1.32, including 498 males (19.46±1.32) and 907 females (19.74±1.31). We found a highly statistical difference between the age of male and female students among college students (t-test: 3.8220: p-value: 0.0001). The majority of students were belonging to the Hindu community (n=964) in contrast to Muslims (n=412) and with minorities including Sikhs and Buddhists n=27 and n=2 respectively (Table 1) (Figure 2A). Regarding the martial estimates, the frequency of married students was not quite high (0.49%) (Table 1). Lifestyle activity of students has been also observed where it is found the lower frequency of alcohol usage 1.35% (n=19/1405) in which the male participants represent the dominancy 72.68% (n=14/19) over the female 26.31% (n=5/19).

Also, the increased smoking habit was observed in males 71.42% (n=15/21) in contrast to female students 28.57% (n=6/21). Around 1190 students (84.69%) were observed to do physical activities including n=450 males (37.81%) and n=740 female (62.18%) (Figure 2E) (Table 1). Regarding the dietary pattern, it was observed that 32.95% (n=463) were non-vegetarian (n=766) were vegetarian and 12.52% (n=176) take both (veg % and non veg.) and with respect to the caffeine 69.89% (n=982) were taken caffeine out of which32.29% (n=327) were occasional (Figure 2B) (Table 1). Stress was found in 60.49% students (n=850/1405) with the male representing 34% (n=290/850) and female 65.88% (n=560/850). We observed statistically significant difference (t-test = 3.3926, p-value: 0.0007) between the age difference between stressed males (19.46±1.33) and females (19.78±1.29).

The frequency of the different types of stress was observed (Table 2) and the educational stress was at the top representing 46.35% including 34.82% (n=101/290) and females 52.32% (n=293/560) (Figure 2F). Different disorders were observed in students which include hypertension 2.70% (n=38/1405), PCOS (Poly-cystic ovarian syndrome) 2.34% (n=33/1405), and depression 2.84% (n=40/1045). To find out the risk attribute associated the condition Odds ratio (OR) were utilized. Stress was found associated with the headache OR: 3.67,95% CI: 2.92-4.60, (p value: <0.0001), PCOS with OR: 3.62 [95% CI: 1.4850-8.84, p-value: 0.0047], hypertension OR: 5.31 [95% CI: 2.06-13.70, p-value: 0.0006] and depression OR: 7.24 [95% CI: 2.56-20.48, p-value: 0.0002]. Also, caffeine risk on hypertension and PCOS were also observed including OR: 5.24 [95% CI: 1.60-17.17, p-value: 0.0061] and OR: 3.12 [95% CI: 1.13-9.34, p-value: 0.027] respectively.

We also observed the bidirectional association of headache and hypertension and found a significant increase of risk i.e., headache to hypertension OR: 14.65, 95% CI: [6.59-32.57], (p-value: 0.0001) and hypertension to headache OR: 3.61, 95% CI: [1.64-7.94] (p-value: 0.0014). Stress was also found significantly (p value <0.0001) associated with the risk of anxiety (OR: 2.66, 95% CI: [2.07-3.43] and risk of stomachache (OR: 2.26, 95% CI: [1.17-2.85]) (Table 3). Educational stress was found significant (p value: <0.0001) responsible for increasing the likely hood of headache by 3.8-fold (OR:3.84, 95% CI: 2.92-5.05). Emotional stress was found to be a high-risk variable associated with hypertension with an OR: 2.74 [95% CI: 1.35-5.54, p-value: 0.0050]. Also, the association between emotional stress and PCOS was observed with an OR: 1.14 [95% CI: 0.50-2.58] but did not reach at statistical significance (p-value: 0.74).

Discussion

Education has a crucial role in society since it may influence people’s attitudes, ways of thinking, and behaviors [12]. But stress which is an inevitable part of life has a detrimental effect on student’s physical and emotional health as well as their academic performance. In the present study, we observed that college female students were more stressed than the male participants, with the female group showing higher levels of educational stress (Figure 3F). Also, emotional stress was found to be more frequent in the female group as compared to the male students (Figure 3F). College students experience stress due to increased workload, new responsibilities, poor time management, and interpersonal relationships [13].

In comparison to our study, many research studies have provided significant data on stress and students and their relationship. According to Waghachavare and colleagues, 25.1% of medical students, 28.7% of dentistry students, and 19.7% of engineering students reported feeling stressed out. In comparison to the gender disparity, female students were found to be more stressed than the male participants [14-16]. According to published data, secondary school students had a medium degree of tension, with females being shown to be more stressed [17]. In the college institution, more than one-fifth of college students suffer from mental problems [18] and the academic domain was the most common source of stress, followed by the social activity area, and group activity domain [19]. Regarding the academic domains, science, and commerce domains students were shown to be more academically stressed than the students in the arts, management stream, and humanities [20]. The fact is that most of the female respondents feel stress in their college life because of fear of failure [21,22].

Reasons for the stress among the students were found the lack of appropriate support, a variety of personal and social issues, academic pressure, extracurricular activities, assignments overburden, and most importantly parents want their children to participate in the rat race and outperform their peers to improve their social status, the attitude of faculty members [16,23,24]. Rana and colleagues reviewed that stress can be either bad or positive for a person, depending on the severity and duration of the stress, the person’s personality, cognitive assessment of the stress, and social support. They must be raised in a positive environment and more attention is paid to the child’s growth as they enter adolescence [7]. Extreme stress can make it difficult to work effectively, as well as cause poor academic achievement and reported poor health and a lower quality of life [13] and there was no association between high-stress levels and students’ age [15].

The biological aspect of stress is complicated where stress has much negative feedback. One such example is the stress-induced stimulation of the hypothalamus to secrete CRH (Corticotrophin releasing hormone) which then further stimulates the anterior part of the pituitary gland to release ACTH (Adrenocorticotropic hormone) [25]. ACTH flows down from the brain to the kidney through the bloodstream (endocrine signaling) and binds to the specific receptor on the Adrenal gland (located on the kidney) and stimulus to secrete the adrenaline and cortisol. Adrenaline and cortisol alter the homeostatic mechanism of the different systems including heart rate, dilation of bronchioles, increasing blood pressure, increasing blood glucose level by converting glycogen, and decreasing digestive activity (Figure 4). Long-term and continuous stimulus results in a dysregulated mechanism which leads to different diseases such as heart diseases [26], asthma [27], Obesity, Diabetes [28], headaches including migraine [11], depression [29] and anxiety [30], gastrointestinal problems [31], Alzheimer’s disease [32] etc. (Figure 5).

In the present study, we have observed that stress negatively impacted the reproductive health of females where it significantly increases the chance of PCOS (Poly-cystic Ovarian Syndrome) OR: 3.62 [95% CI: 1.4850-8.84, p-value: 0.0047]. Also, structural changes in blood vessels i.e., hypertension found to be significantly associated with stress with OR: 5.31 [95% CI: 2.06- 13.70, p-value: 0.0006]. Mental status among students is the seed for progress but stress has created a distressing environment for the brain and alters its normal activity. We have also observed that stress increases 7 times more chance of depression among students with OR: 7.24 [95% CI: 2.56-20.48, p-value: 0.0002]. Emotional stress was found to be a high-risk variable associated with hypertension with an OR: 2.74 [95% CI: 1.35-5.54, p-value: 0.0050]. Also, the association between emotional stress and PCOS was observed with an OR: 1.14 [95% CI: 0.50-2.58] but was not reached statistical significance (p-value: 0.74). Students have a lot of stress related to their academics, where we found that educational stress is significantly associated with the increased likelihood of headache (OR:3.84).

PCOS results in low self-esteem which causes the majority of psychiatric conditions, such as depression and suicide [9]. Stressrelated factors such as Salivary Amylase Activity (SAA) and salivary cortisol levels were found to be higher in PCOS patients than in age-matched controls, implying an exaggerated response of the central stress stations in the affected women [33,34]. Early life stress such as abuse, and school bullying play a significant effect on the susceptibility to develop FGD (Functional Gastrointestinal Disorders) and IBD (Inflammatory Bowel Disease) later in life [35], gastrointestinal conditions like peptic ulcer disease (PU) and ulcerative colitis (UC). Psychological stress has been found to negatively impact the immune system which worsens the number of skin and hair conditions like psoriasis, alopecia areata, and atopic dermatitis [36].

Humensky and group have shown that self-reported depressive symptoms were associated with concentration difficulties and difficulty completing school tasks between 14 to 21 aged students in the United States were at risk for major depression [37]. One-fifth of college students had mental problems, indicating that mental health is a serious problem that increases with the children’s grade level [18]. These findings imply that there is a strong link between stress or stress-related factors and altered body composition. Also headache and hypertension has been found to be linked with each other (comorbid conditions) [38,39] and this might be due to the presence of diverse risk attributes such as environmental including stress and genetic factors [40].

To this end, the future of any nation lies in its students, who are blessed with incredible abilities; we simply need to discover them. Despite of advanced learning and teaching approach, enhancement of students is not at its peak. Stress is a major reason for the decreased development of students which negatively impacted their health, social status, future goals, their academic life, and many other important life aspects. Therefore, emphasizing the value of research, improving pupils’ growth may be accomplished by suggesting some coping mechanisms like college students should pay attention to their health and nutrition, take proper sleep, manage their time effectively, practice self-care, make connections with others, maintain healthy relations, focus on physical activities, use relaxation techniques like meditation, live organized life, practice positive thinking etc. All of these will help college students to increase their overall health and can reduce stress. Avoiding stress decreases and increases the likelihood of disease occurrence and happy and healthy existence respectively.

Conclusion

If a healthy solution cannot be found, stress can have a negative influence on academic performance and mental health. Therefore, there must be needed a system that will ensure a better education system. Colleges must develop coping strategies to reduce stress triggers and improve student experiences by identifying the causes of stress (financial struggles, academic pressure, studentteacher relationship, conflict with a roommate, family issues, relationship issues, career problems, post-graduation plans etc.) which disrupts student’s daily activities and how to manage it.

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Friday, July 14, 2023

Stress Among College Students is Linked to Headache, PCOS, Hypertension, and Depression: A Cross-Sectional Study - Juniper Publishers

 Psychology and Behavioral Science - Juniper Publishers

Abstract

Objective: In the present study, we aimed to find out the prevalence of stress among college students.

Methods: In this descriptive cross-sectional study, a simple random sampling approach was chosen for data collection from different colleges of Jammu & Kashmir (UT). Data analysis was done by using the chi-square test, and the t-test was utilized for discrete and continuous variables respectively. The logistic regression model using odds ratio was utilized to find out the association between the risk variable and the dependent variable.

Results: A total of 1405 college students were included in which stress was found in 60.49% of students with males representing 34% and females 65.88%. Educational stress was found to be the major contributor of stress-type faced by the students with 46.35%. Different disorders were also observed in students including hypertension 2.70%, PCOS (Poly-cystic ovarian syndrome) 2.34%, and depression 2.84%. Stress was found associated with the PCOS with OR: 3.62 [95% CI: 1.4850-8.84, p-value: 0.0047], headache OR: 3.67, hypertension OR: 5.31 [95% CI: 2.06-13.70, p-value: 0.0006] and depression OR: 7.24 [95% CI: 2.56-20.48, p-value: 0.0002].

Conclusion: Educational stress is found to be very common among college students which may alter the prosperous life of students. Female students were seen to be more stressed than male students. Stress has a strong detrimental impact on students’ health because it is considerably linked to conditions including hypertension, PCOS, and depression. Therefore, the educational system must need a better strategy that will ensure a better education system.

Keywords: Stress; Educational stress; Hypertension; PCOS; College students

Abbreviations: PCOS: Poly-cystic ovarian syndrome; SAA): Salivary Amylase Activity; FGD: Functional Gastrointestinal Disorders; IBD: Inflammatory Bowel Disease; PU: Peptic Ulcer; UC: Ulcerative Colitis; CRH: Corticotrophin Releasing Hormone; ACTH: Adrenocorticotropic hormone; OR: Odds Ratio; OECD: Organization for Economic Co-operation and Development

Introduction

In today’s world, many shortcomings need to be eliminated and education is the one that is often seen as a solution to many social problems. Education is an important instrument that has the power to make a person interactive, self-reliant, social, and disciplined. Education broadens the scope of learning by facilitating knowledge absorption and dissemination among people in order to advance society [1]. Every individual is bombarded with a multitude of perceptual information in their day-to-day life activities. Apart from such advantageous features of education, the ability to process information is limited and varies from person to person. These cognitive characteristics have the potential to disrupt students’ lives periodically, which might result in circumstances that resemble stress and anxietylike condition. According to physiological definition, stress may be described as “any form of change that results in bodily, emotional, or psychological strain or pressure”.

It could result from a traumatic, disappointment, or uneasy encounter or sensation [2]. It is not that stress is bad, “Eustress” describes stress as a “positive, motivating, and enhances functioning feature which leads to the excellent performance” while “distress” refers to bad and overwhelming stress full condition which leads to tiredness, despair, and a variety of other illnesses and thus impairs functioning [3]. Albeit intense or transient pressure can be helpful but ongoing pressure, which goes and remains for a more extended period, is very unfavorable to the body and causes hypertension, weight gain, sadness, and even coronary diseases [4]. The effects of anxiety on students’ academic performance were detrimental [5] and besides anxiety, another emotionally uncomfortable disorder that could interfere with a student’s life is depression.

Stress affects students’ life in a variety of ways, including how they perform academically, socially, physically, and emotionally [6]. Exam stress, a lack of interest in attending lectures, full schedules &responsibilities, lack of sleep, an inability to understand the topic, and academic pressure (pressure to achieve high marks and concerns about receiving poor grades) are some examples of stresses faced by students [7]. The cognitive system becomes overburdened under stressful settings, reducing the student’s attention and ability to process the perceived information [8]. Biologically, stress can lead to long-term health complications, chronic illness, and psychiatric conditions such as migraine, PCOS (poly Cystic Ovarian Syndrome), depression, and suicide [9-11].

The Organization for Economic Co-operation and Development (OECD) recently conducted a survey that included 540,000 students aged 15-16 years old from 72 nations which showed that education and academic achievement are major sources of stress for students [5]. Therefore, in the present study, we aim to find out the stress frequency among college students of Jammu division. To our knowledge, this is the first study that included 10 district colleges from our region. The remainder of the paper is laid out as follows: methods utilized in this study are depicted in Section 2, section 3 includes the result of the study, section 4 represents the discussion and the conclusion of the study is present in section 5.

Method

In this present descriptive cross-sectional study, a random sampling approach was chosen for data collection from different colleges in the Jammu division of Jammu & Kashmir (UT). The sample collection was done in two phases i.e., Phase-I (Face-face interview) and Phase-II (E-based sampling).

Sample Collection

A targeted survey was taken in the colleges of the Jammu division to gather data from the different college students. The information was gathered using two different phases, including face-to-face interviews (Phase-I) conducted by an experienced interviewer/ trained interviewer and online sampling/ E-Sampling using a google form (Phase-II). The questionnaire/ Google form was disseminated through emails and social networking sites. The present study design was duly approved by Animal and Human Experimentation Ethical Committee (AHEEC), University of Jammu vide notification number EC: DRS/22/4969.

Filtering and Data Cleaning

A large data set was obtained using the E-based sampling approach, and the data was cleaned and filtered using a variety of exclusion criteria to decrease redundancy and bias. Exclusion criteria include “students that did not belong from the district of Jammu division”, “non-college students”, “who don’t permit for use of their data (incomplete consent)”, and also the exclusion of subject data “who gave the partial information”.

Data analysis and statistics

For the descriptive data analysis, mean with Standard deviation and frequency distribution were used for the continuous and discrete variables respectively. The chi-square test and the t-test were utilized for the discrete and continuous variables, respectively, in the inferential statistics. The logistic regression model utilizing the odds ratio (OR) was used to determine whether the risk variable and the dependent variable i.e., diseases were associated or not. Online free statistical tools/calculators such as MedCalc’s Odds ratio calculator for calculation of Odds ratio, t-test were calculated by graph-pad Home-GraphPad and for chi-square statistics Social Science Statistics (socscistatistics.com) were used to draw out the inference.

Result

A total of 1405 college students were included with a mean age of 19.64±1.32, including 498 males (19.46±1.32) and 907 females (19.74±1.31). We found a highly statistical difference between the age of male and female students among college students (t-test: 3.8220: p-value: 0.0001). The majority of students were belonging to the Hindu community (n=964) in contrast to Muslims (n=412) and with minorities including Sikhs and Buddhists n=27 and n=2 respectively (Table 1) (Figure 2A). Regarding the martial estimates, the frequency of married students was not quite high (0.49%) (Table 1). Lifestyle activity of students has been also observed where it is found the lower frequency of alcohol usage 1.35% (n=19/1405) in which the male participants represent the dominancy 72.68% (n=14/19) over the female 26.31% (n=5/19).

Also, the increased smoking habit was observed in males 71.42% (n=15/21) in contrast to female students 28.57% (n=6/21). Around 1190 students (84.69%) were observed to do physical activities including n=450 males (37.81%) and n=740 female (62.18%) (Figure 2E) (Table 1). Regarding the dietary pattern, it was observed that 32.95% (n=463) were non-vegetarian (n=766) were vegetarian and 12.52% (n=176) take both (veg % and non veg.) and with respect to the caffeine 69.89% (n=982) were taken caffeine out of which32.29% (n=327) were occasional (Figure 2B) (Table 1). Stress was found in 60.49% students (n=850/1405) with the male representing 34% (n=290/850) and female 65.88% (n=560/850). We observed statistically significant difference (t-test = 3.3926, p-value: 0.0007) between the age difference between stressed males (19.46±1.33) and females (19.78±1.29).

The frequency of the different types of stress was observed (Table 2) and the educational stress was at the top representing 46.35% including 34.82% (n=101/290) and females 52.32% (n=293/560) (Figure 2F). Different disorders were observed in students which include hypertension 2.70% (n=38/1405), PCOS (Poly-cystic ovarian syndrome) 2.34% (n=33/1405), and depression 2.84% (n=40/1045). To find out the risk attribute associated the condition Odds ratio (OR) were utilized. Stress was found associated with the headache OR: 3.67,95% CI: 2.92-4.60, (p value: <0.0001), PCOS with OR: 3.62 [95% CI: 1.4850-8.84, p-value: 0.0047], hypertension OR: 5.31 [95% CI: 2.06-13.70, p-value: 0.0006] and depression OR: 7.24 [95% CI: 2.56-20.48, p-value: 0.0002]. Also, caffeine risk on hypertension and PCOS were also observed including OR: 5.24 [95% CI: 1.60-17.17, p-value: 0.0061] and OR: 3.12 [95% CI: 1.13-9.34, p-value: 0.027] respectively.

We also observed the bidirectional association of headache and hypertension and found a significant increase of risk i.e., headache to hypertension OR: 14.65, 95% CI: [6.59-32.57], (p-value: 0.0001) and hypertension to headache OR: 3.61, 95% CI: [1.64-7.94] (p-value: 0.0014). Stress was also found significantly (p value <0.0001) associated with the risk of anxiety (OR: 2.66, 95% CI: [2.07-3.43] and risk of stomachache (OR: 2.26, 95% CI: [1.17-2.85]) (Table 3). Educational stress was found significant (p value: <0.0001) responsible for increasing the likely hood of headache by 3.8-fold (OR:3.84, 95% CI: 2.92-5.05). Emotional stress was found to be a high-risk variable associated with hypertension with an OR: 2.74 [95% CI: 1.35-5.54, p-value: 0.0050]. Also, the association between emotional stress and PCOS was observed with an OR: 1.14 [95% CI: 0.50-2.58] but did not reach at statistical significance (p-value: 0.74).

Discussion

Education has a crucial role in society since it may influence people’s attitudes, ways of thinking, and behaviors [12]. But stress which is an inevitable part of life has a detrimental effect on student’s physical and emotional health as well as their academic performance. In the present study, we observed that college female students were more stressed than the male participants, with the female group showing higher levels of educational stress (Figure 3F). Also, emotional stress was found to be more frequent in the female group as compared to the male students (Figure 3F). College students experience stress due to increased workload, new responsibilities, poor time management, and interpersonal relationships [13].

In comparison to our study, many research studies have provided significant data on stress and students and their relationship. According to Waghachavare and colleagues, 25.1% of medical students, 28.7% of dentistry students, and 19.7% of engineering students reported feeling stressed out. In comparison to the gender disparity, female students were found to be more stressed than the male participants [14-16]. According to published data, secondary school students had a medium degree of tension, with females being shown to be more stressed [17]. In the college institution, more than one-fifth of college students suffer from mental problems [18] and the academic domain was the most common source of stress, followed by the social activity area, and group activity domain [19]. Regarding the academic domains, science, and commerce domains students were shown to be more academically stressed than the students in the arts, management stream, and humanities [20]. The fact is that most of the female respondents feel stress in their college life because of fear of failure [21,22].

Reasons for the stress among the students were found the lack of appropriate support, a variety of personal and social issues, academic pressure, extracurricular activities, assignments overburden, and most importantly parents want their children to participate in the rat race and outperform their peers to improve their social status, the attitude of faculty members [16,23,24]. Rana and colleagues reviewed that stress can be either bad or positive for a person, depending on the severity and duration of the stress, the person’s personality, cognitive assessment of the stress, and social support. They must be raised in a positive environment and more attention is paid to the child’s growth as they enter adolescence [7]. Extreme stress can make it difficult to work effectively, as well as cause poor academic achievement and reported poor health and a lower quality of life [13] and there was no association between high-stress levels and students’ age [15].

The biological aspect of stress is complicated where stress has much negative feedback. One such example is the stress-induced stimulation of the hypothalamus to secrete CRH (Corticotrophin releasing hormone) which then further stimulates the anterior part of the pituitary gland to release ACTH (Adrenocorticotropic hormone) [25]. ACTH flows down from the brain to the kidney through the bloodstream (endocrine signaling) and binds to the specific receptor on the Adrenal gland (located on the kidney) and stimulus to secrete the adrenaline and cortisol. Adrenaline and cortisol alter the homeostatic mechanism of the different systems including heart rate, dilation of bronchioles, increasing blood pressure, increasing blood glucose level by converting glycogen, and decreasing digestive activity (Figure 4). Long-term and continuous stimulus results in a dysregulated mechanism which leads to different diseases such as heart diseases [26], asthma [27], Obesity, Diabetes [28], headaches including migraine [11], depression [29] and anxiety [30], gastrointestinal problems [31], Alzheimer’s disease [32] etc. (Figure 5).

In the present study, we have observed that stress negatively impacted the reproductive health of females where it significantly increases the chance of PCOS (Poly-cystic Ovarian Syndrome) OR: 3.62 [95% CI: 1.4850-8.84, p-value: 0.0047]. Also, structural changes in blood vessels i.e., hypertension found to be significantly associated with stress with OR: 5.31 [95% CI: 2.06- 13.70, p-value: 0.0006]. Mental status among students is the seed for progress but stress has created a distressing environment for the brain and alters its normal activity. We have also observed that stress increases 7 times more chance of depression among students with OR: 7.24 [95% CI: 2.56-20.48, p-value: 0.0002]. Emotional stress was found to be a high-risk variable associated with hypertension with an OR: 2.74 [95% CI: 1.35-5.54, p-value: 0.0050]. Also, the association between emotional stress and PCOS was observed with an OR: 1.14 [95% CI: 0.50-2.58] but was not reached statistical significance (p-value: 0.74). Students have a lot of stress related to their academics, where we found that educational stress is significantly associated with the increased likelihood of headache (OR:3.84).

PCOS results in low self-esteem which causes the majority of psychiatric conditions, such as depression and suicide [9]. Stressrelated factors such as Salivary Amylase Activity (SAA) and salivary cortisol levels were found to be higher in PCOS patients than in age-matched controls, implying an exaggerated response of the central stress stations in the affected women [33,34]. Early life stress such as abuse, and school bullying play a significant effect on the susceptibility to develop FGD (Functional Gastrointestinal Disorders) and IBD (Inflammatory Bowel Disease) later in life [35], gastrointestinal conditions like peptic ulcer disease (PU) and ulcerative colitis (UC). Psychological stress has been found to negatively impact the immune system which worsens the number of skin and hair conditions like psoriasis, alopecia areata, and atopic dermatitis [36].

Humensky and group have shown that self-reported depressive symptoms were associated with concentration difficulties and difficulty completing school tasks between 14 to 21 aged students in the United States were at risk for major depression [37]. One-fifth of college students had mental problems, indicating that mental health is a serious problem that increases with the children’s grade level [18]. These findings imply that there is a strong link between stress or stress-related factors and altered body composition. Also headache and hypertension has been found to be linked with each other (comorbid conditions) [38,39] and this might be due to the presence of diverse risk attributes such as environmental including stress and genetic factors [40].

To this end, the future of any nation lies in its students, who are blessed with incredible abilities; we simply need to discover them. Despite of advanced learning and teaching approach, enhancement of students is not at its peak. Stress is a major reason for the decreased development of students which negatively impacted their health, social status, future goals, their academic life, and many other important life aspects. Therefore, emphasizing the value of research, improving pupils’ growth may be accomplished by suggesting some coping mechanisms like college students should pay attention to their health and nutrition, take proper sleep, manage their time effectively, practice self-care, make connections with others, maintain healthy relations, focus on physical activities, use relaxation techniques like meditation, live organized life, practice positive thinking etc. All of these will help college students to increase their overall health and can reduce stress. Avoiding stress decreases and increases the likelihood of disease occurrence and happy and healthy existence respectively.

Conclusion

If a healthy solution cannot be found, stress can have a negative influence on academic performance and mental health. Therefore, there must be needed a system that will ensure a better education system. Colleges must develop coping strategies to reduce stress triggers and improve student experiences by identifying the causes of stress (financial struggles, academic pressure, studentteacher relationship, conflict with a roommate, family issues, relationship issues, career problems, post-graduation plans etc.) which disrupts student’s daily activities and how to manage it.

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Wednesday, May 26, 2021

Anesthesia Management in a Patient with Synthetic Cannabinoid Dependence: A Case Report - Juniper Publishers

 Juniper Online Journal of Public Health - Juniper Publishers


Abstract

Patients with synthetic cannabinoid dependence can hide themselves because of their fear. The suspicious approach of the anesthesiologist to these cases, careful preoperative examination, plays an important role in solving the problems that may be encountered in the preoperative and postoperative period.

Keywords: Synthetic cannabinoid dependence; Hypertension; Tachycardia; Anesthesia, Dependence; Public health problem

Abbreviations: NIBP: Noninvasive Blood Pressure; HR: Heart Rate; ECG: Electrocardiogram; CHS: Cannabinoid Hyperemesis Syndrome; IV: Intravenously

Introduction

Synthetic cannabinoid dependence is a serious public health problem. Synthetic cannabinoids have increased in popularity among drug addicts in recent years. Anesthesiologists also encounter patients with synthetic cannabinoid dependence more frequently. Synthetic cannabinoids may have cardiovascular, respiratory and neurological effects in anesthetized patients. In this article, anesthesia management in a dependent patient with tachycardia and hypertension is shared.

Case Report

A 24-year-old male patient who was scheduled for appendectomy operation had no systemic disease or drug use in his preoperative examination. Noninvasive blood pressure (NIBP) 178/106 mmHg, heart rate (HR) 122/min, electrocardiogram (ECG), respiratory sounds and chest radiography were normal. The patient was evaluated as ASA 1E. Laboratory tests were normal except white blood cell 16×103/μL(4,511,00×103/ μL), aspartate aminotransferase 65 U/L (<31 U/L), alanine aminotransferase 58 U/L (<33 U/L). In the operating room, he was anxious, NIBP 185/120 mmHg, HR 135/min, and peripheral oxygen saturation was 97%. I asked to the patient again if there was any disease or drug use. It was learned that he had been using synthetic cannabinoid for 3 years. He stated that; he could not say before, because his family was near him in the surgical department. The last substance use was 18 hours ago. There was no history of ICU stay due to synthetic cannabinoid use. Although the patient was hypertensive and tachycardic, anesthesia was given to the patient because of the emergency operation. Rapid sequence intubation with cricoid compression was planned. The patient was hypertensive and tachycardic after induction and intubation, and invasive artery monitoring was performed. The dose of remifentanil infusion was increased.

Propofol 1 mg/kg was administered intravenously (iv) to increase the depth of anesthesia, to the tachycardic and hypertensive patient. The dose of remifentanil was increased to 1mcq/kg/ min. The patient was still hypertensive in the followup, and esmolol infusion was started at a dose of 50mcq/kg/min. Paracetamol 1000 mg and tramadol 1 mg/kg were administered for postoperative analgesia. Perioperative systolic BP was 185- 140 mmHg, diastolic BP was 120-95 mmHg, and HR was 115- 160 / min. At the end of the 45-minute operation, the patient was extubated after sugammadex 4 mg/kg iv administration. The artery catheter was removed. The patient’s systolic BP was between 148 and 135 mmHg, diastolic BP was between 85 and 75 mmHg, and HR was between 110 to 120/min in the post anesthesia care unit. No additional medication was administered during the 1-hour follow-up. When modified aldrete score of the patient was 9, he was sent to the surgical department with recommendations.

Discussion

Cocaine, heroin, opioids, amphetamines and synthetic cannabinoids are commonly used by addicts. The use of synthetic cannabinoids has increased in recent years due to their cheap and easy accessibility [1,2]. Cannabinoids; endocannabinoids (naturally found in humans), phyto cannabinoids (produced from plants) and synthetic cannabinoids (chemical production) are divided into three groups (2). Synthetic cannabinoids are used by inhalation, orally or intravenously. They act via CB1 and CB2 receptors [3]. CB1 receptors are responsible for the effects of cannabinoids such as cardiovascular, euphoria, anxiety and are mainly located in the limbic system, hippocampus and basal ganglions [4]. CB2 receptors which in immune mediated cells are responsible for anti-inflammatory effects [4].

A carefully preoperative examination in substance addicts plays a key role in resolving the problems that the anesthesiologist may encounter in the perioperative or postoperative period. Knowing the substance used is important in terms of determining the dose of anesthetic medication, preventing possible withdrawal syndrome and awareness in anesthesia [5]. There was no evidence of substance addiction in the presented case. If cardiovascular problems are suspected due to the substance dependence, echocardiography should be performed. There was no cardiac sound or murmur in the presented case, ECG was tachycardic but normal sinus rhythm. Also, ECG of the patient was normal sinus rhythm during the follow-up in post anesthesia care unit. Respiratory depression and atelectasis may be seen in patients with substance use by inhalation for a long time, and pulmonary edema or pleural effusion may be seen on chest radiographs [6]. Pulmonary sounds and chest radiography of the presented case were normal.

Cannabinoid hyperemesis syndrome (CHS) was described in 2004 [7]. Cannabinoid hyperemesis syndrome, which is seen in synthetic cannabinoid addicts with severe nausea and vomiting attacks, is important for anesthesiologists [7]. Rapid sequence intubation was performed in this patient, and any complications did not develop during ventilation and intubation. Delusions, hallucinations, blurred consciousness, bradycardia, tachycardia, hypertension, hypotension, arrhythmia, coronary artery disease, liver failure, gastritis, peptic ulcer and renal failure may also be seen in the patients with synthetic cannabinoid dependence [6]. Although most of these problems can be detected preoperatively, some of them may be seen in the peroperative or postoperative period. All these symptoms and diseases are important for the anesthesiologist and can change the anesthesia plan. There was no pathological laboratory finding except mild liver enzyme elevation and leukocytosis in the presented case.

Conclusion

As synthetic cannabinoid dependence increases, anesthesiologists will encounter these patients more frequently in operating rooms. There are many studies on treatment approaches in patients with synthetic cannabinoid dependence in emergency and intensive care units. However, studies are limited in terms of anesthesia applications. Therefore, I think it will be beneficial to make more studies about anesthesia management in these patients.

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Monday, September 28, 2020

SARS-CoV-2 Infection and Diabetes/strong - Juniper Publishers

 Current Research in Diabetes & Obesity - Juniper Publishers

Abstract

 The outbreak of severe acute respiratory infections is being one of the most serious risks to global health. In early December 2019, many pneumonia cases with unknown reason emerged in Wuhan, Hubei, China. Sequencing the samples from lower respiratory tract, scientists have revealed a novel coronavirus that was named 2019 novel coronavirus (SARS-CoV-2). The most common symptoms identified were: fever, dry cough and dyspnoea. Thus, doctors were concerned about the possibility that patients with cardiovascular disease, diabetes or other chronic diseases were more exposed to complications.

It is now well known that human pathogenic coronaviruses (severe acute respiratory syndrome coronavirus [SARS-CoV] and SARS-CoV-2) bind to their target cells through angiotensin-converting enzyme 2 (ACE2), which is expressed by the epithelial cells of the lung, intestine, kidney and blood vessels. The expression of ACE2 is mainly increased in patients with hypertension treated with ACE-inhibitors and in patients with diabetes. This could explain why these patients are more susceptible to the infection and its severe consequences, including death. Actually, current literature has shown a relation between metabolic comorbidities and a worse outcome for Covid-19 infection. The aim of this short report is to report the current knowledge on the relation between hyperglycaemia, diabetes and severity of SARS-CoV-2 infection.

Keywords: COVID-19; Diabetes; ACE2; Obesity; Hypertension; IL-6

Abbreviations: SARS-CoV-2: 2019 Novel Coronavirus; SARS-CoV: Severe Acute Respiratory Syndrome Coronavirus; ACE2: Angiotensin-Converting Enzyme 2; ROS: Reactive Oxygen Species; IL-6: Interleukin-6

Introduction

In December 2019, several cases of respiratory infections in humans were reported in Wuhan, China [1]. The recognized pathogen was a novel virus, named “2019 novel coronavirus (SARS-CoV-2)” and was first isolated on 7 January 2020. Since then, the virus has spread worldwide and has infected 1 914 916 patients globally, causing 123 010 deaths as of 15 April 2020 [2]. The SARS-CoV-2 is an enveloped, single-stranded RNA virus that can be transmitted from human to human through respiratory droplets [3]. Moreover, since SARS-CoV-2 RNA has been detected in the stool of some patients, faecal-oral transmission could be possible [4]. The phylogenetic analysis revealed that COVID-19 is potentially a zoonotic virus. According to the similarity of SARS-CoV-2 to bat SARS-CoV-like coronaviruses, it is likely that bats serve as reservoir hosts for its progenitor [3]. The most common symptoms at onset of COVID-19 disease are fever, cough and fatigue. Other symptoms include headache, haemoptysis, diarrhoea, dyspnoea. Older people and patients with pre-existing medical conditions such as high blood pressure, heart disease, lung disease, cancer and diabetes appear to develop serious illness more often than others [5].

Several investigations have demonstrated a higher susceptibility to some infectious diseases in patients with diabetes, probably because of a dysregulation of the immune system. In fact, diabetes is a multifactorial metabolic disease, characterized by insulin resistance, glucose intolerance and hyperglycaemia [6]. A recent study reported that the mortality rate of COVID-19 in patients with diabetes and without other comorbidities is about 16% [7]. Hence, we review the current clinical evidence of the correlation between diabetes and COVID-19 infection.

Diabetes and Inflammation

Nowadays it is well known that chronic hyperglycaemia accelerates the formation of advanced glycation end products and increased levels of free fatty acids and stimulates the production of inflammatory mediators and reactive oxygen species (ROS) [8]. It is proposed that systemic immune activation and pro-inflammatory cytokines are central to the development of micro- and macro-vascular complications associated to chronic hyperglycaemia, particularly in obese patients with type 2 diabetes [9]. In addition, the inflammation related to obesity is characterized by an increased activation of innate and adaptive immunity cells in adipose tissue with an increased release of inflammatory factors and chemokines locally and systemically [10].

Several studies on SARS-CoV showed that a known history of diabetes and an ambient hyperglycaemia, before any steroid therapy, are independent predictors of morbidity and mortality, due to the consequent inflammation and the hypoxia of the tissues. In this way, hyperglycaemia might reflect the multisystem involvement and underline the high risk of death among diabetic patients developing SARS [11]. More importantly, the normalization of blood glucose levels with the suppression of ketosis are able to reduce mortality and morbidity especially in diabetic patients [12].

Therefore, diabetes seems to worsen the outcome of viral infections as already happened with the 2003 severe acute respiratory syndrome due to SARS-CoV or the H1N1 infection. This seems to be the case also for patients affected by COVID-19. In fact, people with diabetes have a low grade of chronic inflammation that could facilitate the progression of the typical ‘cytokine storm’ that has been shown to be the cause of severe cases of COVID-19 infection [13]. Cytokine release syndrome is a systemic inflammatory response, which can be caused by infection, some drugs and other factors, characterized by a sharp increase in the level of a large number of pro-inflammatory cytokines [14]. A retrospective study in Wuhan has shown that among different markers of inflammation (C-reactive protein, fibrinogen, D-dimer), interleukin-6 (IL-6) seems to be the more represented in diabetic patients than in patients without diabetes [7].

The IL-6 has a pleiotropic activity on inflammation and immunity. Usually, it induces the synthesis of acute phase proteins whereas it inhibits the production of albumin. Moreover, IL-6 stimulates the acquired immune response and promotes the proliferation of several non-immune cells [15]. Therefore, the increased synthesis of IL-6 could play a relevant effect and lead to the ‘cytokine storm’ associated with the COVID-19 infection. During this inflammatory storm, the D-dimer increases significantly. This iper-inflammation can also lead to an overall hypercoagulable state or even disseminated intravascular coagulation. The presence of higher level of D-dimer and fibrinogen and higher production of pro-inflammatory cytokines in patients with diabetes could indicate that they are also more inclined to present a hypercoagulable state than patients without diabetes. These data show that COVID-19 patients with diabetes are at higher risk of excessive uncontrolled inflammation responses and hypercoagulable state, which may contribute to poorer prognosis of COVID-19 [16].

The Role of ACE-2 Receptor

COVID-19, like others coronaviruses (SARS-CoV in 2003), uses a specific ACE2 receptor to invade cells, particularly type II pneumocytes. Many studies also confirm, through biophysical and structural analysis, that the 2019-nCoV S protein binds angiotensin-converting enzyme 2 (ACE2) with higher affinity than severe acute respiratory syndrome (SARS-CoV) [17,18]. It is well known that ACE-2 receptor can be found in lung, kidney, heart and also in the pancreatic islets. In some studies, it has been described that the severity of the disease and damage to several organs (lung, kidney, liver) is related to organ expression of ACE2. The localization of ACE2 in the endocrine part of the pancreas suggests that SARS-CoV enters islets using ACE2 as its receptor and may potentially cause acute hyperglycaemia and diabetes [19]. Therefore, it is possible to speculate that SARS-CoV2 could act in a similar way and worsen diabetes control in patients with diabetes or induce hyperglycaemia in non-diabetic patients. Preliminary reports showed that hyperglycaemia may be present in more than 50% of patients with the novel COVID-19 infection [20]. Interestingly, previous studies on SARS-CoV in 2003, have demonstrated that hyperglycaemia is an independent predictor of death and sometimes diabetes have occurred during the course of SARS. Usually, hyperglycaemia has been transient [21]. These consequences could be explained by the fact that SARS-CoV and SARS-CoV2 can damage islets cells and reduce insulin production [22].

Conclusion

According to a retrospective study led to Wuhan, almost 20% of the patients affected by COVID-19 had diabetes as underlying disease with poorer prognosis [23]. Another study, of about 150 patients (68 deaths and 82 recovered patients) in Wuhan, showed that the number of comorbidities is a significant predictor of mortality [24]. The most distinctive comorbidities of 32 nonsurvivors from a group of 52 intensive care unit patients with novel coronavirus disease 2019 (COVID-19) were cerebrovascular diseases (22%) and diabetes (22%) [25]. A report of 72,314 cases of COVID-19 published by the Chinese Centre for Disease Control and Prevention showed increased mortality in people with diabetes (2.3%, overall and 7.3%, patients with diabetes) [26]. These data are important to define that an impairment of glucose metabolism may significantly affect the prognosis of COVID-19. In fact, these patients show a higher mortality rate, which further support the hypothesis that diabetes is a risk factor for the prognosis of COVID-19. It is possible that there is a one to one relationship between COVID-19 infection and diabetes due on the one hand to the chronic inflammation typical of the diabetic patient and on the other hand to the direct invasion of pancreatic islets by the virus. Further studies are needed to better understand the pathophysiological mechanism underlying this process.

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Artificial Intelligence System for Value Added Tax Collection via Self Organizing Map (SOM)- Juniper Publishers

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