Evaluation of Pre-Transplant Risk Factors as Independent Predictors on the New Onset of Diabetes after Renal Transplants (NODAT)- Juniper Publishers

Juniper Publishers- Open access journal of Endocrinology and Thyroid

Authored by Debmalya Sanyal

One of the most potential complications in renal allograft recipients is post- operative impaired glucose tolerance leading to frank de novo Diabetes Mellitus known as New Onset Diabetes after Transplant (NODAT). It is multifactorial and is pathogenically similar to Type 2 Diabetes Mellitus. Having a variable incidence, it is usually associated with an increased risk of infection, cardiovascular morbidity, and graft dysfunction which can eventually cause mortality or loss of the allograft. In this study we aimed at comparing pre-operative risk factors namely age, sex, gender, insulin resistance (estimated by HOMA-IR), ß cell function (estimated by HOMA-ß), pre-operative fasting plasma glucose, post-operative fasting plasma glucose, tacrolimus level, induction ATG and hepatitis C virus status as an implicating factor for those who developed NODAT in post-operative period versus those who maintained an euglycemic status throughout the study period (non-NODAT). The study was carried out at the renal transplant unit of NHRTIICS, Kolkata between Jan 2013 to Feb 2014.

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Tyrosine Kinase Inhibitors: A Foe for the Thyroid? (JETR) - Juniper Publishers

Juniper publishers- Open access journal of Endocrinology and thyroid

Tyrosine Kinase Inhibitors: A Foe for the Thyroid? in Juniper in Journal of Endocrinology and Thyroid Research

Tyrosine kinase inhibitors (TKIs) are agents that inhibit multiple receptor tyrosine kinases that are implicated in tumour growth, neoangiogenesis and metastatic progression of cancer. The simultaneous inhibition of these targets leads to both reduced tumor vascularization and increased cancer cell death, and ultimately tumor shrinkage. Several multi target TKIs are approved and have been associated with thyroid dysfunction [1]. Although anticancer treatment with the TKIs frequently causes thyroid dysfunction, the underlying mechanism implicated along with related clinical features have not been fully elucidated until today. 

https://juniperpublishers.com/jetr/pdf/JETR.MS.ID.555555.pdf

https://juniperpublishers.com/jetr/JETR.MS.ID.555555.php

Dietary Intake Omega-3 Rich Fish Oil and Management of Diabetes (JETR) - Juniper Publishers

Juniper publishers-Open access journal of Endocrinology and Thyroid

Dietary Intake Omega-3 Rich Fish Oil and Management of Diabetes in Juniper in Journal of Endocrinology and Thyroid Research (JETR)

Diabetes mellitus is a multifactorial disorder and prolonged suffering from the diabetes leads to damage the several vital organs due to excessive oxidative stress. On the other hand, omega-3 polyunsaturated fatty acids prevent the oxidative stress as evidenced from the various literatures. Therefore, we hypothesized the dietary intake of omega-3 rich fish oil could be beneficial in the management of diabetes and thus protect the several organs from the oxidative damages. Diabetes was induced in Swiss albino mice, Mus musculus, by repeating the intra peritoneal injection of Alloxan (100mg / kg body weight). Half of the diabetic mice were fed ad libitum the pellet feed blended with10% laboratory extracted fish oil from Sardinella longiceps for one month in the laboratory. Various biochemical parameters pertaining to oxidative stress were measured along with the histology of the various organs like heart, kidney, liver and pancreas and the expression of certain cytokines and other m RNAs was measured by one step reversed PCR. The results suggest the prophylactic effect of dietary intake of Sardinella oil in diabetic mice by regulating the expression of cytokines and other marinas along with the increase of ant oxidant molecules in various organs.

https://juniperpublishers.com/jetr/pdf/JETR.MS.ID.555554.pdf

https://juniperpublishers.com/jetr/JETR.MS.ID.555554.php