CRISPR/ Cas9: A Toolbox with Clinical Potential-Juniper Publishers

CRISPR/ Cas9: A Toolbox with Clinical Potential in Juniper in International Journal of Cell Science & Molecular Biology (IJCSMB)

The CRISPR/ Cas9 machinery, which is known to provide adaptive immunity to bacteria and archeae, has been proven an efficient tool for genome editing in a wide range of organisms. It is an RNA-guided DNA endonuclease that introduces double-stranded breaks in the target DNA. This compact machinery has been adapted and is being widely used for precise editing and modification of the genome [1]. This review focuses on genome editing using the CRISPR/ Cas9 system for correction of genetic diseases. Here, we review examples from literature where the CRISPR/ Cas9 system has been used for the correction of Duchenne Muscular Dystrophy (DMD), cataract caused due to mutations in the Crygc gene, cystic fibrosis, and sickle cell disease. 

https://juniperpublishers.com/ijcsmb/pdf/IJCSMB.MS.ID.555554.pdf

https://juniperpublishers.com/ijcsmb/IJCSMB.MS.ID.555554.php

Effects of Cadmium Toxicity on Bio-distribution of Trace Elements in Normal and Protein Malnourished Rats-Juniper Publishers

Effects of Cadmium Toxicity on Bio-distribution of Trace Elements in Normal and Protein Malnourished Rats in Juniper in International Journal of Cell Science & Molecular Biology (IJCSMB)

Cadmium is an established toxic metal with its ability to accumulate in blood, liver and kidney. Cadmium is chemically related to zinc and found wherever zinc occurs in nature. It is emitted to air and water by mines, metal foundries and industries using Cadmium in alkaline accumulators, alloys, paints and plastics. Cadmium is known to alter the tissue distribution of the essential trace metals like Zn, Cu and Fe this effect has been shown to be associated with many of the toxic effects of cadmium like anemia and anosmia. Protein malnutrition enhances the susceptibility to cadmium intoxication which affects metabolism of essential trace elements; Zn, Fe and Cu were studied, in normal and protein under-nourished rats. Estimation of metals was done routinely in samples of urine and tissue (brain, liver, kidney and blood) in rats of dietary groups, 21% and 8%, after 120 days of Cd exposure, 50ppm, through drinking water. Significant aberrations in levels of the essential elements Zn, Fe and Cu were reported in both urine and tissues.

https://juniperpublishers.com/ijcsmb/pdf/IJCSMB.MS.ID.555553.pdf

https://juniperpublishers.com/ijcsmb/IJCSMB.MS.ID.555553.php

Melanuria in the melanoma with reference to the urinary bladder: Brief history - Juniper Publishers

Melanuria in the melanoma with reference to the urinary bladder: Brief history in Juniper in IJCSMB

The far famed, weighty work of Willis on metastasis contains two statements on melanuria on the basis of the urinary bladder and even the liver. Therefore, this paper considers further evidences based on collating sufficient materials from The Transactions of the Pathological Society of London. The findings included wide ranging discussion of melanuria by the old masters themselves as well as at present. 

https://juniperpublishers.com/ijcsmb/pdf/IJCSMB.MS.ID.555552.pdf

https://juniperpublishers.com/ijcsmb/IJCSMB.MS.ID.555552.php