Friday, March 1, 2019

Cytotoxicity Effects of LPR-1®, CCE100 and ONCOBLOC® on a Panel of Cancer Cell Lines- Juniper Publishers

JUNIPER PUBLISHERS-Journal of Complementary Medicine & Alternative Healthcare



Cytotoxicity Effects of LPR-1®, CCE100 and ONCOBLOC® on a Panel of Cancer Cell Lines


Authored by Lim Yang Mooi,

LPR-1®, CCE100 and ONCOBLOC® are LPR-1® Standardized C. militaris (L.) Link Extract (LSc 1501) Conventional Cordyceps extract (100X concentration) and ONCOBLOC® standardized novel C. militaris (L.) Link extract (SLS-161), respectively. All these three extracts are obtained from C. militaris through conventional and proprietary extraction processes. These extracts possess a broad spectrum of chemoprotective properties against free radicals and oxidative stress. In this study, the cytotoxicity ONCOBLOC® were assessed against 24 human cancer cell lines using MTT of LPR-1®, CCE100 and cytotoxicity assay. In addition, the cytotoxic effects of these extracts were benchmarked to chemotherapy drug, doxorubicin on a panel of cancer cell lines. From the results obtained, LPR-1® showed cytotoxicity to HONE-1, NCI-H23 and Fa Du cells; CCE100 caused cytotoxicity to HONE-1, Fa Du, T-47D, MCF-7 and U-2 OS cells; whereas ONCOBLOC® exhibited cytotoxicity to HONE-1, FaDu, T-47D, MDA- MB-231 and K-562. Among the 24 cancer cells, ONCOBLOC® showed the strongest cytotoxic effects against nasopharyngeal carcinoma epithelial cell line (HONE-1), with the IC50 value of 15.34^g/mL. These preliminary results suggest that ONCOBLOC® possesses promising anti-cancer activities and could be developed as a novel anticancer agent. Hence, more efficacy studies will be carried to confirm its anti cancer properties.

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