Tyrosine Kinase Inhibitors: A Foe for the Thyroid? (JETR) - Juniper Publishers

Juniper publishers- Open access journal of Endocrinology and thyroid

Tyrosine Kinase Inhibitors: A Foe for the Thyroid? in Juniper in Journal of Endocrinology and Thyroid Research

Tyrosine kinase inhibitors (TKIs) are agents that inhibit multiple receptor tyrosine kinases that are implicated in tumour growth, neoangiogenesis and metastatic progression of cancer. The simultaneous inhibition of these targets leads to both reduced tumor vascularization and increased cancer cell death, and ultimately tumor shrinkage. Several multi target TKIs are approved and have been associated with thyroid dysfunction [1]. Although anticancer treatment with the TKIs frequently causes thyroid dysfunction, the underlying mechanism implicated along with related clinical features have not been fully elucidated until today. 

https://juniperpublishers.com/jetr/pdf/JETR.MS.ID.555555.pdf

https://juniperpublishers.com/jetr/JETR.MS.ID.555555.php

Adiponectin, Diabetes and Coronary Artery Disease (JETR) - Juniper Publishers

Juniper publishers- Open access journal of Endocrinology and thyroid

Adiponectin, Diabetes and Coronary Artery Disease in Juniper in Journal of Endocrinology and Thyroid Research (JETR)

White adipose tissue is an active endocrine gland communicates with the brain and the peripheral tissue including pancreatic beta cell through adipocytokines [1]. Examples of adipokines are; acylation stimulating protein (ASP), adiponectin, adipsin, angiotensinogen, bone morphogenic protein (BMP), estrogen, insulin-like growth factor-1 (IGF-1), various IGF binding proteins, interleukins (ILs), leptin, monocyte chemoattractant protein 1 (MCP-1), plasminogen activator I (PAI-1), resistin, TNF-alpha, transforming growth factorbeta (TGF-beta) and various prostaglandins [2-8] (Figure 1).

https://juniperpublishers.com/jetr/pdf/JETR.MS.ID.555553.pdf

https://juniperpublishers.com/jetr/JETR.MS.ID.555553.php