Role of Toll like Receptor(s) in Tumor Biology in Juniper in Journal of Tumor Medicine & Prevention
Toll like receptors belong to a family of specialized immune receptors that highly conserved and specific for their ligands. TLR signaling can identify specific pathogen and can induce expression of inflammatory cytokines, chemokines, initiate opsonization and phagocytosis, elicit reactive oxygen/nitrogen species production, activate the complement pathway etc. to get rid of it. Apart from its unquestionable role in pathogen recognition and neutralization, TLRs can also identify altered self-proteins including those expressed by transformed cell. Agonists of toll like receptors, both of natural or synthetic origin have been exploited for their ability to elicit and/or potentiate anticancer response alone or when combined with available treatment regimes. TLR agonist mediated activation of immune cells (lymphocytes, leukocytes etc.) and production of inflammatory mediators leads to the generation of cellular (adaptive) immune responses that hold promising applications
against cancer progression.
against cancer progression.
