JUNIPER PUBLISHERS-Journal of Tumor Medicine & Prevention
JAK2 and Its Regulators beyond Myeloproliferative Neoplasms
Authored by Nahla A M Hamed*
Dysregulated JAK2 is at the apex of
three classic oncogenic signaling cascades including STAT, PI3K/Akt/mTOR, and
MAPK pathways. Their interrelationship and dependencies downstream of JAK2 in
MPN cells is incompletely understood. Combined pathway inhibition in vitro
might prove beneficial due to a synergistic impact on functionally redundant
oncogenic axes, might allow lower doses of the different agents with better
tolerability, and might avoid or delay the development of resistance.
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