Tuesday, November 27, 2018

Anti-Apoptotic Effect of Semelil on Testicular Germ Cells in Streptozotocin-lnduced Chronic Diabetic Rats


Authored by Maryam Anjomshoa

It is well known that diabetes is associated with impairment of testicular function. The present study aimed to investigate the effect of Semilil, an herbal medicine with angiogenic action, on testicular germ cell apoptosis in streptozotocin (STZ)-induced chronic diabetic rats. Adult Male sprague dawley rats were divided into 5 groups: (1) diabetic group, (2) Semilil-treated diabetic group, (3) insulin- treated diabetic group, (4) Semilil plus insulin-treated diabetic group, and (5) control group. Semilil was administered intraperitoneally at the dose of 13mg/kg for 49 days. Apoptosis in testicular germ cells was determined by terminal-deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL) staining. Apoptosis indices in testicular germ cells of animals were computed using the stereologic method.

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