Relationship of Gelatynase B Enzyme Activity and Coronary Artery Disease-Juniper Publishers-Biostatistics and Biometrics Open Access Journal

JUNIPER PUBLISHERS-BIOSTATISTICS AND BIOMETRICS OPEN ACCESS JOURNAL

Relationship of Gelatynase B Enzyme Activity and Coronary Artery Disease

Authored by Aysegul Bayramoglu

Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of atherosclerosis, the pathology underlying the majority of coronary artery disease (CAD). We planned to investigate the association of enzyme activities of gelatinase B (or matrix metalloproteinase-9) in CAD patients. For this reason,102 patients with CAD and 99 control group recruited in this study. Serum gelatinase B enzyme level determinated from these peripheral blood samples by using Enzyme-Linked Immunosorbent Assay (ELISA). The results were evaluated by using statistical analyses. The level of gelatinase B increased in patients according to control group. As a result of our study, serum gelatinase B level was associated with CAD and could be used as a clinical marker.

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