Juniper publishers- Open access journal of Endocrinology and thyroid
Tyrosine Kinase Inhibitors: A Foe for the Thyroid? in Juniper in Journal of Endocrinology and Thyroid Research
Tyrosine kinase inhibitors (TKIs) are agents that inhibit multiple receptor tyrosine kinases that are implicated in tumour growth, neoangiogenesis and metastatic progression of cancer. The simultaneous inhibition of these targets leads to both reduced tumor vascularization and increased cancer cell death, and ultimately tumor shrinkage. Several multi target TKIs are approved and have been associated with thyroid dysfunction [1]. Although anticancer treatment with the TKIs frequently causes thyroid dysfunction, the underlying mechanism implicated along with related clinical features have not been fully elucidated until today.
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