JUNIPER PUBLISHERS-Journal of Pharmacology & Clinical Research
A New Promising Method of Hepatitis Treatment at the Level of Ultrastructure of the Liver by Standardized Powder form of Magnetite Nanoparticles (Micromage-B)
Authored by Andrey N Belousov*
In order to determine ultra structural reconstructions in
hepatic cells under effect of magnetite nanoparticles, an experiment was
conducted on 37 rabbits. Micromage-B at a dose of 25 mg was dissolved in 10 ml
of drinking water. Micromage-B is standardized powder form of magnetite
nanoparticles. Every day the rabbit had a drink of 0.25% colloidal solution of
magnetite nanoparticles for 7 days. The study ultra structural changes of
hepatocytes were performed on the 8th day. Analysis of the state of
submicroscopic architectonics of hepatic cells in rabbits after using
Micromage-B reveals a significant activation of metabolic intracellular
processes in these organs. Ultra structural organization of the liver testifies
about intensification of synthetic intracellular processes, it being
structurally manifested by enlargement of cisterns in the rough endoplasmic
reticulum, an increased number of ribosomes, a moderate hypertrophy of the
laminar cytoplasmic Goldi’s complex. For the first time in the study was the
evidence of the possibility of using powder form of magnetite nanoparticles
Micromage-B as an effective means of non-specific activation of metabolic
processes in the liver at the ultrastructural level.
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