JUNIPER PUBLISHERS-Advances in Biotechnology & Microbiology
Antifungal Resistance and its Evolution: An Increasing Concern
Authored by Claudia Ortiz*
This work describes different
mechanism of drug resistance and some aspects of evolution of fungi in order to
evade antifungal effects. Fungal infections are an issue of concern, and it is
necessary to develop new strategies in order to mitigate mortality rates caused
by these types of pathogens. However, fungi exhibit different resistance
mechanisms, ranging from genetic mutations to metabolic adaptations to the
action of several antifungal compounds available for clinical treatments.
However, some antifungal resistance are no-evident and need to be studied in
order to avoid rising of new resistant fungal strains. Moreover, it is well
known that drug resistance is linked to fungal evolution. For this reason, it
is important to understand adaptation mechanisms carried out by fungi to resist
antibiotic action, such as aminoacid mutations or different metabolic responses
of fungal species to several antifungal drugs, in order to, design both new
antifungal compounds or strategies for treating fungal infections.
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