Coupling Genetic Addiction Risk Score (GARS) and Pro Dopamine Regulation (KB220) to Combat Substance Use Disorder (SUD) by Kenneth Blum in Global Journal of Addiction & Rehabilitation Medicine - Juniper Publishers
RDS conceptualization:The biological processes of reward that underlie addiction
to substances and all addictive, compulsive and impulsive behaviors are the basis of the RDS conceptualization [5,6]. RDS
then is a deficiency, a hypodopaminergic condition that results
from some combination of genetic variations, environmental
stressors, and adverse molecular effects or blunting due to
prolonged substance use or behavioral habituation [7-9]. The
RDS concept was developed based on animal and human research
that explored the molecular biology of neurotransmission, and
behavioral genetics [8,10,11]. Understanding this concept,
explained in the following paragraphs, is central to treating
the abnormal psychology of personality and spectrum
disorders, as well as, substance and non-substance (behavioral)
addictions. To feel ordinary pleasure, complex interactions of
neurotransmitters regulate the dopaminergic activity of the
brain in the reward center -the mesolimbic system, particularly
the nucleus accumbens. Individuals, who suffer from a lack of
ordinary pleasure in their lives, are predisposed to use any
means; substance or behavior, to activate dopamine release,
relieve stress and feel healthy pleasure [12,13].
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