Dendritic Cells and Regulatory T Cells Changes During ECP for Chronic GvHD in Pediatric Patients-Open Access Blood Research & Transfusion Journal-Juniper Publishers

JUNIPER PUBLISHERS-Open Access Blood Research & Transfusion Journal

Dendritic Cells and Regulatory T Cells Changes During ECP for Chronic GvHD in Pediatric Patients

Authored by Berger Massimo*

Graft-versus-host disease (GvHD) is a leading cause of post HSCT morbidity and mortality. It is mediated by alloreactive mature donor T lymphocytes, resulting in a harmful inflammatory response and tissue injury . The pathophysiology of GvHD is constituted by precise sequences of immunological events such as the activation of antigen-presenting cells (APCs), activation, differentiation and migration of T cells, and finally the development of their full effector functions. Dendritic cells (DCs) constitute the most professional APCs, promoting alloreactivity or clonal antigen-specific T cell responses. Moreover, tolerogenic DCs may play a pivotal role in GvHD exerting an immunomodulatory or even immunosuppressive effect on T cells. DCs can be divided into two major subsets, plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) which have distinct functions. pDCs play a pivotal role in peripheral tolerance through the generation of regulatory T (Treg). In addition to pDCs, mDCs also promote Th2 and Th0/Tr1 responses, depending on the activation signal types.

For Read More... Fulltext click on: https://juniperpublishers.com/oabtj/OABTJ.MS.ID.555597.php

For More Articles in Open Access Blood Research & Transfusion Journal Please Click on:

https://juniperpublishers.com/oabtj/index.php

For More Open Access Journals In Juniper Publishers Please Click on:

https://juniperpublishers.com/index.php