In vivo Acute Toxicity (LD50) Studies and Phytochemical Screening of Stem Bark Extracts of Detarium microcarpum Guilt and per (Caesalpinioideae) and Myosortisscorpioides L. (boraginaceae) by Abdu Zakari in Juniper Publishers in Current Trends in Biomedical Engineering & Biosciences
The methanol extract of stem bark of Detarium microcarpum and Myosortisscorpioides were screened for in vivo safety pharmacological studies (acute toxicity LD50) using Swiss Albino Miceand for the presence of some phytochemicals. The result of the phytochemical screening indicated the presence of important secondary metabolites including alkaloids, saponins, tannins, anthraquinones, carbohydrates, flavonoids. The results showed that the plant extracts were toxic to the mice and caused death at a concentration of =2900mg/Kg and 1600mg/kg body weight of the live mice and LD50 of 3,807.89mg/Kg and =2,828.43mg/Kg respectively. The result of the study was a useful guide to a practically safe dose in an ongoing antimalarial study of extracts of these plants.
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