JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF TOXICOLOGY
Crotalus lepidus lepidus Venom Produces Hemolysis
and Lipid Peroxidation in Human Erythrocytes
in vitro in Juniper in Open Access Journal of Toxicology
The hemolytic and lipid peroxidative effects of crude venom from Crotalus lepidus lepidus, a rattle snake found in the Northeast of Mexico and southeast of the United States, were investigated in human erythrocytes in vitro. Significant concentration-dependent effects were found on both hemolysis (evaluated as release of hemoglobin) and lipid peroxidation (as a common index of oxidative damage to membrane lipids) in the red blood cells. These results suggest that hemolysis was produced with the involvement of oxidative stress as a potential mechanism of toxicity in the erythrocytes.
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