JUNIPER PUBLISHERS-Organic & Medicinal Chemistry International Journal
Quinoline-Substituted 1,2,3-Triazole-Based Molecules, As Promising Conjugated Hybrids in Biomedical Research
Authored by Vladimir V
Kouznetsov*
Building a single molecular framework
containing quinoline and triazoles rings of promising biological activity
through molecular hybridization strategy offers the viewpoint of better drugs
for the treatment of a number of diseases including cancer, malaria,
tuberculosis and other illnesses. Presenting modified selectivity profile,
different and/or dual modes of action and reduced undesired side effects, these
molecular hybrids are gaining momentum worldwide showing their promise in drug
discovery. Such hybrid molecules are usually made efficiently through click
chemistry technique using multicomponent reactions. In this paper, we discuss
chemistry and biology of some quinoline-substituted 1,2,3-triazole hybrids
aiming at a better understanding of physicochemical properties of
quinoline-triazole hybrids for designing novel bioactive chemical entities. So,
principal Lipinski’ parameters and in silico study (lipophilicity and molecular
polar surface area) are also briefly mentioned and applied to selected
quinoline-1,2,3-triazole hybrids. The mini-review is divided in two general
parts: synthetic aspects of the preparation of these hybrids and their
pharmacological aspects paying attention to the widespread dangerous diseases
such as malaria, cancer, and human fungal infections, especially systemic
mycoses.
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