JUNIPER PUBLISHERS-Global Journal of Otolaryngology
Human Papilloma Virus Epidemiology and Subtyping in Head and Neck Squamous Cell Carcinoma by Anatomical Site in Central Greece
Authored by Charalampos Skoulakis*
To assess Human Papilloma Virus (HPV)
prevalence and subtypes distribution in a population of Head and Neck Squamous
cell carcinoma (HNSCC) patients in Central Greece. Paraffin-embedded biopsy
samples from 90 patients with confirmed HNSCC, were retrospectively analysed
for the presence of various HPV sub-types via real time PCR. In addition, a
total of 206 controls, who visited the ENT Department the same period, were
also tested for the presence of HPV sub-types in their pharyngeal cavity, by
the same molecular assay. According to the anatomical site, HNSCC originated
from four different sites: oral cavity, oropharynx, larynx, and hypopharynx.
The presence of HPV was detected in 42.2% of samples (38/90), while the most
prevalent subtype was HPV-16 (89.5%; 34/38), followed by HPV-18 (%), HPV-31 and
HPV-33(%). Amongst the HPV(+) HNSCC samples, most originated from the oral
cavity (45%, 17/38) and the oropharynx (32%, 12/38). On the other hand, among
the non-HNSCC controls, 9.7% (20/206) were HPV positive, while the most
prevalent sub-types were HPV-31, HPV-56, HPV-45 and HPV-41 (Table 1); moreover,
six samples were positive for more one subtypes. Statistical analysis revealed
that HPV (+) patients were 7 times more likely to have HNSCC [OR 6.8, 95%CI
3.65–12.67, p<0.0005], and HPV-16 (+) patients were 124 times more likely to
have HNSCC [OR 124.5, 95%CI 16.67–929.3, p<0.0005].High prevalence of HPV
was detected in HNSCC patients in Central Greece, where HPV-16 predominate. Our
results demonstrate the necessity of the 9-valent HPV vaccination.
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