A Case of Vitamin D Toxicity-Novel Approaches in Drug Designing & Development-Juniper Publishers

JUNIPER PUBLISHERS-Novel Approaches in Drug Designing & Development

A Case of Vitamin D Toxicity

Authored by Joseph L Borowit

An eighty four year old Caucasian male started taking glucosamine for joint health two years previously. He failed to notice that the glucosamine tablets also contained large doses of cholecalciferol, a precursor of vitamin D. According to the label on the container, two tablets each having five times the recommended daily amount (RDA) were to be taken every day. This was in addition to the vitamin D taken in milk at breakfast, and that in half gram calcium tablets taken twice daily and also vitamin D in a multiple vitamin preparation. All together this added up to 6000 international units (IU) of the vitamin taken each day. The RDA for older people is 800 IU. So he was taking 7.5 times the RDA of vitamin D for over a year. When he discovered the overdose, he stopped taking vitamin D except for milk at breakfast. Symptoms noted during vitamin D intoxication were mostly central nervous system effects (nervousness, insomnia, irritability, clumsiness) not uncommon in an eighty four year old man. These symptoms persisted for several months even after cessation of vitamin D overdose but gradually decreased in intensity. Submandibular pain also occurred but went away after correcting the overdose. Arthritis also occurred in the knee joints but this did not abate after cessation of the overdose. Reversible Parkinsonism is also seen in vitamin D intoxication. Some increase in tremor was evident in the patient during the overdose but the tremor gradually became less intense with increased time without the vitamin supplement.

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