JUNIPER PUBLISHERS-Journal of Head Neck & Spine Surgery
Role of MiRNAs in Oral Cancer
Authored by Bin Guo*
Oral cancer, one of the most common
cancers worldwide, exhibits high mortality and morbidity rates. The incidence
rate of oral cancer is high in developing countries, especially in Asian
countries. MiRNAs are non-coding RNAs with significant regulatory functions, such
as mRNA degradation or translation inhibition. Understanding of the
tumorigenesis of oral cancer has significantly progressed at multiple levels.
MiRNAs play an important role in oral tumors and have been associated with
specific oral cancer phenotypes, such as tumorigenesis, progression,
recurrence, or postoperative survival. MiRNAs exist stably in common body
fluids and are thus ideal biomarkers for oral cancer. The miRNA profiles
hallmark a potential diagnostic value for detection of oral cancer and potentially
malignant disorders. In this review, we will summarize our current knowledge
regarding the most active miRNAs involved in oral cancer, focusing our
discussion on their role in tumor diagnosis, development, and progression.
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