Wednesday, May 15, 2019

Intrauterine Insemination with Fresh Versus Cryopreserved Spermatazoa in Unexplained Infertility-Global Journal of Reproductive Medicine-Juniper Publishers

JUNIPER PUBLISHERS-Global Journal of Reproductive Medicine

Intrauterine Insemination with Fresh Versus Cryopreserved Spermatazoa in Unexplained Infertility


Authored by Sheena Rippentrop*

The purpose of this study was to compare pregnancy rates and live birth rates in women with unexplained infertility undergoing ovulation induction and intrauterine insemination (IUI) using fresh versus cryopreserved semen at two institutions. Retrospective cohort study conducted at two tertiary care centers via chart review of all women with unexplained infertility who underwent IUI. Other etiologies of infertility were excluded. Pregnancy, clinical pregnancy, and live birth rates were calculated in both groups. Odds ratios and 95 % confidence interval were calculated. A P-value was considered significant when less than 0.05. A total of 566 IUI cycles were analyzed; 513cycles (90.64%) used fresh semen while 59 cycles (10.42%) used cryopreserved. Clinical pregnancy rates were 29.24% in IUI-fresh and 11.32% in IUI-cryopreserved (OR 3.24, 95% CI 1.36-7.73, p-value 0.0055). The live birth rate per cycle for IUI-fresh was 19.88% versus 3.77% in IUI-cryopreserved (OR 6.33, 95% CI 1.52-26.43, p-value 0.0044). Significantly higher pregnancy rates and live birth rates were observed when using fresh semen compared to cryopreserved semen in women with unexplained infertility undergoing ovulation induction and intrauterine inseminations.

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